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Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Huber S, et al. Among authors: esplugues e. Immunity. 2011 Apr 22;34(4):554-65. doi: 10.1016/j.immuni.2011.01.020. Immunity. 2011. PMID: 21511184 Free PMC article.
Control of TH17 cells occurs in the small intestine.
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Esplugues E, et al. Nature. 2011 Jul 17;475(7357):514-8. doi: 10.1038/nature10228. Nature. 2011. PMID: 21765430 Free PMC article.
Bcl6 expression specifies the T follicular helper cell program in vivo.
Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Liu X, et al. Among authors: esplugues e. J Exp Med. 2012 Sep 24;209(10):1841-52, S1-24. doi: 10.1084/jem.20120219. Epub 2012 Sep 17. J Exp Med. 2012. PMID: 22987803 Free PMC article.
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA. Gagliani N, et al. Among authors: esplugues e. Nature. 2015 Jul 9;523(7559):221-5. doi: 10.1038/nature14452. Epub 2015 Apr 29. Nature. 2015. PMID: 25924064 Free PMC article.
37 results