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Nelumbo nucifera Petals Ameliorate Depressive-like Symptom and Cognitive Deficit in Unpredictable Chronic Mild Stress Mouse Model.
Maneenet J, Chotritthirong Y, Omar AM, Choonong R, Daodee S, Monthakantirat O, Khamphukdee C, Pitiporn S, Awale S, Matsumoto K, Chulikhit Y. Maneenet J, et al. Nutrients. 2024 Dec 29;17(1):94. doi: 10.3390/nu17010094. Nutrients. 2024. PMID: 39796528
Furthermore, a phytochemical analysis resulted in the isolation of five major compounds, kaempferol (1), trifolin (2), kaempferol-3-neohesperidoside (3), icariside D(2) (4), and beta-sitosterol (5), each demonstrating significant monoamine oxidase (MAO) inhibitory a …
Furthermore, a phytochemical analysis resulted in the isolation of five major compounds, kaempferol (1), trifolin (2), kaempferol-3-neohespe …
Inhibitory Activity of N- and S-Functionalized Monoterpene Diols Towards Monoamine Oxidases A and B.
Podturkina AV, Ardashov OV, Soldatova YV, Poletaeva DA, Smolina AV, Vasyuchenko EP, Vyatkin YV, Li-Zhulanov NS, Faingold II, Salakhutdinov NF, Volcho KP. Podturkina AV, et al. Int J Mol Sci. 2024 Dec 26;26(1):97. doi: 10.3390/ijms26010097. Int J Mol Sci. 2024. PMID: 39795958
Monoamine oxidase B (MAO-B) inhibitors are widely used as part of combination drug therapy for Parkinson's disease. ...A molecular docking method for studying murine MAO-A and -B enzymes was developed using AlphaFold2 (v2.3.2), with further improvement …
Monoamine oxidase B (MAO-B) inhibitors are widely used as part of combination drug therapy for Parkinson's disease. ...A molec …
Targeting MAO-B with Small-Molecule Inhibitors: A Decade of Advances in Anticancer Research (2012-2024).
Alsaad I, Abdel Rahman DMA, Al-Tamimi O, Alhaj SA, Sabbah DA, Hajjo R, Bardaweel SK. Alsaad I, et al. Molecules. 2024 Dec 31;30(1):126. doi: 10.3390/molecules30010126. Molecules. 2024. PMID: 39795182 Review.
Monoamine oxidase B (MAO-B) is a key enzyme in the mitochondrial outer membrane, pivotal for the oxidative deamination of biogenic amines. ...Inhibition of MAO-B impedes cell proliferation, making it a potential therapeutic target. Various monoamine oxidas …
Monoamine oxidase B (MAO-B) is a key enzyme in the mitochondrial outer membrane, pivotal for the oxidative deamination of biog …
The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis.
He X, Hu M, Xu Y, Xia F, Tan Y, Wang Y, Xiang H, Wu H, Ji T, Xu Q, Wang L, Huang Z, Sun M, Wan Y, Cui P, Liang S, Pan Y, Xiao S, He Y, Song R, Yan J, Quan X, Wei Y, Hong C, Liao W, Li F, El-Omar E, Chen J, Qi X, Gao J, Zhou H. He X, et al. Nat Med. 2025 Jan 8. doi: 10.1038/s41591-024-03405-9. Online ahead of print. Nat Med. 2025. PMID: 39779925
This accumulation of PEA was primarily driven by decreased monoamine oxidase-B activity in both the liver and serum due to cirrhosis. Targeting PDC or PEA reversed the neurological symptoms induced by R. gnavus. ...
This accumulation of PEA was primarily driven by decreased monoamine oxidase-B activity in both the liver and serum due to cir …
Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets.
Lü J, Jiang C, Drabick JJ, Joshi M, Perimbeti S. Lü J, et al. Pharm Res. 2025 Jan 8. doi: 10.1007/s11095-024-03809-9. Online ahead of print. Pharm Res. 2025. PMID: 39779619
Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/D on androgen and estrogen receptors, D/DA promoting activity for glutamic acid decarboxylase (GAD)- gamma-aminobutyric acid (GABA) inhibito …
Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/ …
Prolactin levels increased by physical exercise correlate with platelet monoamine oxidase activity: Evidence linking platelet MAO with serotonin release capacity.
Harro J, Eensoo D, Suvi S, Timpmann S, Ööpik V. Harro J, et al. Neurosci Lett. 2025 Jan 6;848:138116. doi: 10.1016/j.neulet.2025.138116. Online ahead of print. Neurosci Lett. 2025. PMID: 39778649
OBJECTIVE: Lower platelet monoamine oxidase (MAO) activity has consistently been associated with excessive risk-taking and general psychiatric vulnerability. ...
OBJECTIVE: Lower platelet monoamine oxidase (MAO) activity has consistently been associated with excessive risk-taking and gen …
Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants in Preclinical Studies.
Rosas-Sánchez GU, Germán-Ponciano LJ, Guillen-Ruiz G, Cueto-Escobedo J, Limón-Vázquez AK, Rodríguez-Landa JF, Soria-Fregozo C. Rosas-Sánchez GU, et al. Biomedicines. 2024 Nov 29;12(12):2744. doi: 10.3390/biomedicines12122744. Biomedicines. 2024. PMID: 39767650 Free article. Review.
Pharmacotherapy for depression includes drugs such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors (NaSSAs), and atypical antidepr …
Pharmacotherapy for depression includes drugs such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), …
26,549 results
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