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Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI.
Jones KM, Randtke EA, Howison CM, Cárdenas-Rodríguez J, Sime PJ, Kottmann MR, Pagel MD. Jones KM, et al. Among authors: sime pj. Mol Imaging Biol. 2015 Apr;17(2):177-84. doi: 10.1007/s11307-014-0784-6. Mol Imaging Biol. 2015. PMID: 25187227 Free PMC article.
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.
Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ. Kottmann RM, et al. Among authors: sime pj. Am J Respir Crit Care Med. 2012 Oct 15;186(8):740-51. doi: 10.1164/rccm.201201-0084OC. Epub 2012 Aug 23. Am J Respir Crit Care Med. 2012. PMID: 22923663 Free PMC article.
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.
Jones MG, Andriotis OG, Roberts JJ, Lunn K, Tear VJ, Cao L, Ask K, Smart DE, Bonfanti A, Johnson P, Alzetani A, Conforti F, Doherty R, Lai CY, Johnson B, Bourdakos KN, Fletcher SV, Marshall BG, Jogai S, Brereton CJ, Chee SJ, Ottensmeier CH, Sime P, Gauldie J, Kolb M, Mahajan S, Fabre A, Bhaskar A, Jarolimek W, Richeldi L, O'Reilly KM, Monk PD, Thurner PJ, Davies DE. Jones MG, et al. Among authors: sime p. Elife. 2018 Jul 3;7:e36354. doi: 10.7554/eLife.36354. Elife. 2018. PMID: 29966587 Free PMC article.
172 results