Joachimiak A - Search Results

1

Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.

Vassiliou S, Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Mulligan R, Joachimiak A, Mucha A. Vassiliou S, et al. Among authors: joachimiak a. J Med Chem. 2014 Oct 9;57(19):8140-51. doi: 10.1021/jm501071f. Epub 2014 Sep 22. J Med Chem. 2014. PMID: 25192493 Free PMC article.

2

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA. Zhou HB, et al. Among authors: joachimiak a. J Med Chem. 2007 Jan 25;50(2):399-403. doi: 10.1021/jm061035y. J Med Chem. 2007. PMID: 17228884

3

Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis.

Nocek B, Mulligan R, Bargassa M, Collart F, Joachimiak A. Nocek B, et al. Among authors: joachimiak a. Proteins. 2008 Jan 1;70(1):273-9. doi: 10.1002/prot.21276. Proteins. 2008. PMID: 17876832 Free PMC article. No abstract available.

4

Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism.

Zhao HT, Hazemann I, Mitschler A, Carbone V, Joachimiak A, Ginell S, Podjarny A, El-Kabbani O. Zhao HT, et al. Among authors: joachimiak a. J Med Chem. 2008 Mar 13;51(5):1478-81. doi: 10.1021/jm701514k. Epub 2008 Feb 20. J Med Chem. 2008. PMID: 18284183

5

Structure of SO2946 orphan from Shewanella oneidensis shows "jelly-roll" fold with carbohydrate-binding module.

Nocek B, Bigelow L, Abdullah J, Joachimiak A. Nocek B, et al. Among authors: joachimiak a. J Struct Funct Genomics. 2008 Dec;9(1-4):1-6. doi: 10.1007/s10969-008-9040-0. Epub 2008 Jun 20. J Struct Funct Genomics. 2008. PMID: 18566914 Free PMC article.

6

The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae contains two active-site histidine residues.

Gillner DM, Bienvenue DL, Nocek BP, Joachimiak A, Zachary V, Bennett B, Holz RC. Gillner DM, et al. Among authors: joachimiak a. J Biol Inorg Chem. 2009 Jan;14(1):1-10. doi: 10.1007/s00775-008-0418-z. Epub 2008 Aug 19. J Biol Inorg Chem. 2009. PMID: 18712420 Free PMC article.

7

Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.

Nocek BP, Gillner DM, Fan Y, Holz RC, Joachimiak A. Nocek BP, et al. Among authors: joachimiak a. J Mol Biol. 2010 Apr 2;397(3):617-26. doi: 10.1016/j.jmb.2010.01.062. Epub 2010 Feb 4. J Mol Biol. 2010. PMID: 20138056 Free PMC article.

8

Δ1-pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo.

Forlani G, Petrollino D, Fusetti M, Romanini L, Nocek B, Joachimiak A, Berlicki L, Kafarski P. Forlani G, et al. Among authors: joachimiak a. Amino Acids. 2012 Jun;42(6):2283-91. doi: 10.1007/s00726-011-0970-7. Epub 2011 Jul 9. Amino Acids. 2012. PMID: 21744012 Free PMC article.

9

Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase.

Osipiuk J, Mulligan R, Bargassa M, Hamilton JE, Cunningham MA, Joachimiak A. Osipiuk J, et al. Among authors: joachimiak a. J Biol Chem. 2012 Jun 1;287(23):19452-61. doi: 10.1074/jbc.M112.358069. Epub 2012 Apr 5. J Biol Chem. 2012. PMID: 22493430 Free PMC article.

10

An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.

Węglarz-Tomczak E, Poręba M, Byzia A, Berlicki Ł, Nocek B, Mulligan R, Joachimiak A, Drąg M, Mucha A. Węglarz-Tomczak E, et al. Among authors: joachimiak a. Biochimie. 2013 Feb;95(2):419-28. doi: 10.1016/j.biochi.2012.10.018. Epub 2012 Nov 3. Biochimie. 2013. PMID: 23131591 Free PMC article.

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