Mosier PD - Search Results

1

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK. Polepally PR, et al. Among authors: mosier pd. Eur J Med Chem. 2014 Oct 6;85:818-29. doi: 10.1016/j.ejmech.2014.07.077. Epub 2014 Aug 23. Eur J Med Chem. 2014. PMID: 25193297 Free PMC article.

2

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.

Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Runyon SP, et al. Among authors: mosier pd. J Med Chem. 2008 Nov 13;51(21):6808-28. doi: 10.1021/jm800771x. Epub 2008 Oct 11. J Med Chem. 2008. PMID: 18847250 Free PMC article.

3

Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.

Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Yan F, et al. Among authors: mosier pd. Biochemistry. 2009 Jul 28;48(29):6898-908. doi: 10.1021/bi900605n. Biochemistry. 2009. PMID: 19555087 Free PMC article.

4

Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

Shah JR, Mosier PD, Roth BL, Kellogg GE, Westkaemper RB. Shah JR, et al. Among authors: mosier pd. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. doi: 10.1016/j.bmc.2009.08.016. Epub 2009 Aug 13. Bioorg Med Chem. 2009. PMID: 19700330 Free PMC article.

5

CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity.

McGovern DL, Mosier PD, Roth BL, Westkaemper RB. McGovern DL, et al. Among authors: mosier pd. J Mol Graph Model. 2010 Apr;28(7):612-25. doi: 10.1016/j.jmgm.2009.12.008. Epub 2010 Jan 4. J Mol Graph Model. 2010. PMID: 20083418 Free PMC article.

6

Chemotype-selective modes of action of κ-opioid receptor agonists.

Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Vardy E, et al. Among authors: mosier pd. J Biol Chem. 2013 Nov 29;288(48):34470-83. doi: 10.1074/jbc.M113.515668. Epub 2013 Oct 11. J Biol Chem. 2013. PMID: 24121503 Free PMC article.

7

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Yan F, et al. Among authors: mosier pd. Biochemistry. 2005 Jun 21;44(24):8643-51. doi: 10.1021/bi050490d. Biochemistry. 2005. PMID: 15952771

8

Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.

Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Vortherms TA, et al. Among authors: mosier pd. J Biol Chem. 2007 Feb 2;282(5):3146-56. doi: 10.1074/jbc.M609264200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121830 Free article.

9

Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA. Dukat M, et al. Among authors: mosier pd. J Med Chem. 2008 Feb 14;51(3):603-11. doi: 10.1021/jm070910s. Epub 2008 Jan 18. J Med Chem. 2008. PMID: 18201064 Free PMC article.

10

Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor.

Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Dewkar GK, et al. Among authors: mosier pd. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. doi: 10.1016/j.bmcl.2008.08.059. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2008. PMID: 18774714 Free PMC article.

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