O'Reilly MC - Search Results

1

Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains.

O'Reilly MC, Oguin TH 3rd, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW. O'Reilly MC, et al. ChemMedChem. 2014 Dec;9(12):2633-7. doi: 10.1002/cmdc.201402333. Epub 2014 Sep 10. ChemMedChem. 2014. PMID: 25210004 Free PMC article.

2

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

O'Reilly MC, Scott SA, Brown KA, Oguin TH 3rd, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. doi: 10.1021/jm301782e. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23445448 Free PMC article.

3

Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.

O'Reilly MC, Scott SA, Brown HA, Lindsley CW. O'Reilly MC, et al. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5553-5557. doi: 10.1016/j.bmcl.2014.11.017. Epub 2014 Nov 15. Bioorg Med Chem Lett. 2014. PMID: 25466173 Free PMC article.

4

A general, enantioselective synthesis of protected morpholines and piperazines.

O'Reilly MC, Lindsley CW. O'Reilly MC, et al. Org Lett. 2012 Jun 1;14(11):2910-3. doi: 10.1021/ol301203z. Epub 2012 May 22. Org Lett. 2012. PMID: 22616979 Free PMC article.

5

Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis.

O'Reilly MC, Lindsley CW. O'Reilly MC, et al. Tetrahedron Lett. 2012 Mar 28;53(13):1539-1542. doi: 10.1016/j.tetlet.2011.12.063. Epub 2011 Dec 29. Tetrahedron Lett. 2012. PMID: 22919116 Free PMC article.

6

Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.

Scott SA, Xiang Y, Mathews TP, Cho HP, Myers DS, Armstrong MD, Tallman KA, O'Reilly MC, Lindsley CW, Brown HA. Scott SA, et al. J Biol Chem. 2013 Jul 12;288(28):20477-87. doi: 10.1074/jbc.M113.451708. Epub 2013 May 30. J Biol Chem. 2013. PMID: 23723068 Free PMC article.

7

A general, enantioselective synthesis of β- and γ-fluoroamines.

O'Reilly MC, Lindsley CW. O'Reilly MC, et al. Tetrahedron Lett. 2013 Jul 10;54(28):3627-3629. doi: 10.1016/j.tetlet.2013.04.116. Tetrahedron Lett. 2013. PMID: 24039308 Free PMC article.

8

Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.

Scott SA, Spencer CT, O'Reilly MC, Brown KA, Lavieri RR, Cho CH, Jung DI, Larock RC, Brown HA, Lindsley CW. Scott SA, et al. ACS Chem Biol. 2015 Feb 20;10(2):421-32. doi: 10.1021/cb500828m. Epub 2014 Nov 19. ACS Chem Biol. 2015. PMID: 25384256 Free PMC article.

9

A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis.

Senter TJ, O'Reilly MC, Chong KM, Sulikowski GA, Lindsley CW. Senter TJ, et al. Among authors: o reilly mc. Tetrahedron Lett. 2015 Mar 4;56(10):1276-1279. doi: 10.1016/j.tetlet.2015.01.140. Tetrahedron Lett. 2015. PMID: 26834294 Free PMC article.

10

A General and Scalable Method toward Enantioenriched C2-Substituted Azetidines Using Chiral tert-Butanesulfinamides.

Zelch D, Russo CM, Ruud KJ, O'Reilly MC. Zelch D, et al. Among authors: o reilly mc. J Org Chem. 2024 Oct 18;89(20):15137-15144. doi: 10.1021/acs.joc.4c01908. Epub 2024 Sep 30. J Org Chem. 2024. PMID: 39348268 Free PMC article.

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