West AB - Search Results

1

Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Liu Z, et al. Among authors: west ab. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. J Biol Chem. 2014. PMID: 25228699 Free PMC article.

2

The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.

Sen S, West AB. Sen S, et al. Among authors: west ab. Antioxid Redox Signal. 2009 Sep;11(9):2167-87. doi: 10.1089/ars.2009.2430. Antioxid Redox Signal. 2009. PMID: 19271991 Free PMC article.

3

LRRK2 in Parkinson's disease: function in cells and neurodegeneration.

Webber PJ, West AB. Webber PJ, et al. Among authors: west ab. FEBS J. 2009 Nov;276(22):6436-44. doi: 10.1111/j.1742-4658.2009.07342.x. Epub 2009 Oct 5. FEBS J. 2009. PMID: 19804415 Free PMC article. Review.

4

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

Sen S, Webber PJ, West AB. Sen S, et al. Among authors: west ab. J Biol Chem. 2009 Dec 25;284(52):36346-36356. doi: 10.1074/jbc.M109.025437. Epub 2009 Oct 13. J Biol Chem. 2009. PMID: 19826009 Free PMC article.

5

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.

Pungaliya PP, Bai Y, Lipinski K, Anand VS, Sen S, Brown EL, Bates B, Reinhart PH, West AB, Hirst WD, Braithwaite SP. Pungaliya PP, et al. Among authors: west ab. PLoS One. 2010 Oct 27;5(10):e13672. doi: 10.1371/journal.pone.0013672. PLoS One. 2010. PMID: 21060682 Free PMC article.

6

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB. Webber PJ, et al. Among authors: west ab. J Mol Biol. 2011 Sep 9;412(1):94-110. doi: 10.1016/j.jmb.2011.07.033. Epub 2011 Jul 22. J Mol Biol. 2011. PMID: 21806997 Free PMC article.

7

LRRK2 inhibition attenuates microglial inflammatory responses.

Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. Moehle MS, et al. Among authors: west ab. J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012. J Neurosci. 2012. PMID: 22302802 Free PMC article.

8

LRRK2 secretion in exosomes is regulated by 14-3-3.

Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Fraser KB, et al. Among authors: west ab. Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886663 Free PMC article.

9

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.

West AB, Cowell RM, Daher JP, Moehle MS, Hinkle KM, Melrose HL, Standaert DG, Volpicelli-Daley LA. West AB, et al. J Comp Neurol. 2014 Aug 1;522(11):2465-80. doi: 10.1002/cne.23583. Epub 2014 Apr 12. J Comp Neurol. 2014. PMID: 24633735 Free PMC article.

10

Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.

Daher JP, Volpicelli-Daley LA, Blackburn JP, Moehle MS, West AB. Daher JP, et al. Among authors: west ab. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9. Proc Natl Acad Sci U S A. 2014. PMID: 24927544 Free PMC article.

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