Rosenblum MG - Search Results

1

Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.

Zhou H, Mohamedali KA, Gonzalez-Angulo AM, Cao Y, Migliorini M, Cheung LH, LoBello J, Lei X, Qi Y, Hittelman WN, Winkles JA, Tran NL, Rosenblum MG. Zhou H, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2014 Nov;13(11):2688-705. doi: 10.1158/1535-7163.MCT-14-0346. Epub 2014 Sep 19. Mol Cancer Ther. 2014. PMID: 25239934 Free PMC article.

2

Mechanistic studies of a novel human fusion toxin composed of vascular endothelial growth factor (VEGF)121 and the serine protease granzyme B: directed apoptotic events in vascular endothelial cells.

Liu Y, Cheung LH, Thorpe P, Rosenblum MG. Liu Y, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2003 Oct;2(10):949-59. Mol Cancer Ther. 2003. PMID: 14578460

3

Recombinant single-chain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor.

Liu Y, Cheung LH, Marks JW, Rosenblum MG. Liu Y, et al. Among authors: rosenblum mg. Int J Cancer. 2004 Feb 10;108(4):549-57. doi: 10.1002/ijc.11524. Int J Cancer. 2004. PMID: 14696119

4

Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents.

Liu Y, Cheung LH, Hittelman WN, Rosenblum MG. Liu Y, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2003 Dec;2(12):1341-50. Mol Cancer Ther. 2003. PMID: 14707275

5

The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.

Lyu MA, Cheung LH, Hittelman WN, Marks JW, Aguiar RC, Rosenblum MG. Lyu MA, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2007 Feb;6(2):460-70. doi: 10.1158/1535-7163.MCT-06-0254. Epub 2007 Jan 31. Mol Cancer Ther. 2007. PMID: 17267661

6

Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.

Cao Y, Marks JD, Marks JW, Cheung LH, Kim S, Rosenblum MG. Cao Y, et al. Among authors: rosenblum mg. Cancer Res. 2009 Dec 1;69(23):8987-95. doi: 10.1158/0008-5472.CAN-09-2693. Epub 2009 Nov 24. Cancer Res. 2009. PMID: 19934334

7

Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells.

Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, Winkles JA. Zhou H, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2011 Jul;10(7):1276-88. doi: 10.1158/1535-7163.MCT-11-0161. Epub 2011 May 17. Mol Cancer Ther. 2011. PMID: 21586630 Free PMC article.

8

Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity.

Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong C, Hittelman WN, Wen X, Marks JW, Cheung LH, Boland K, Li C, Adams GP, Rosenblum MG. Cao Y, et al. Among authors: rosenblum mg. Mol Cancer Ther. 2012 Jan;11(1):143-53. doi: 10.1158/1535-7163.MCT-11-0519. Epub 2011 Nov 16. Mol Cancer Ther. 2012. PMID: 22090420

9

Cell-targeting fusion constructs containing recombinant gelonin.

Lyu MA, Cao YJ, Mohamedali KA, Rosenblum MG. Lyu MA, et al. Among authors: rosenblum mg. Methods Enzymol. 2012;502:167-214. doi: 10.1016/B978-0-12-416039-2.00008-2. Methods Enzymol. 2012. PMID: 22208986 Review.

10

Bax345/BLyS: a novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin.

Lyu MA, Cheung LH, Hittelman WN, Liu Y, Marks JW, Cho MJ, Rosenblum MG. Lyu MA, et al. Among authors: rosenblum mg. Cancer Lett. 2012 Sep 28;322(2):159-68. doi: 10.1016/j.canlet.2012.02.029. Epub 2012 Mar 1. Cancer Lett. 2012. PMID: 22388102

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