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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Chan JC, Piper DE, Cao Q, Liu D, King C, Wang W, Tang J, Liu Q, Higbee J, Xia Z, Di Y, Shetterly S, Arimura Z, Salomonis H, Romanow WG, Thibault ST, Zhang R, Cao P, Yang XP, Yu T, Lu M, Retter MW, Kwon G, Henne K, Pan O, Tsai MM, Fuchslocher B, Yang E, Zhou L, Lee KJ, Daris M, Sheng J, Wang Y, Shen WD, Yeh WC, Emery M, Walker NP, Shan B, Schwarz M, Jackson SM. Chan JC, et al. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9820-5. doi: 10.1073/pnas.0903849106. Epub 2009 May 14. Proc Natl Acad Sci U S A. 2009. PMID: 19443683 Free PMC article.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Henne KR, Ason B, Howard M, Wang W, Sun J, Higbee J, Tang J, Matsuda KC, Xu R, Zhou L, Chan JC, King C, Piper DE, Ketchem RR, Michaels ML, Jackson SM, Retter MW. Henne KR, et al. Among authors: chan jc. J Pharmacol Exp Ther. 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4. J Pharmacol Exp Ther. 2015. PMID: 25653417
Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
Gunawardane RN, Fordstrom P, Piper DE, Masterman S, Siu S, Liu D, Brown M, Lu M, Tang J, Zhang R, Cheng J, Gates A, Meininger D, Chan J, Carlson T, Walker N, Schwarz M, Delaney J, Zhou M. Gunawardane RN, et al. Among authors: chan j. J Biol Chem. 2016 Feb 5;291(6):2799-811. doi: 10.1074/jbc.M115.672790. Epub 2015 Dec 7. J Biol Chem. 2016. PMID: 26644477 Free PMC article.
Cardiovascular response to small-molecule APJ activation.
Ason B, Chen Y, Guo Q, Hoagland KM, Chui RW, Fielden M, Sutherland W, Chen R, Zhang Y, Mihardja S, Ma X, Li X, Sun Y, Liu D, Nguyen K, Wang J, Li N, Rajamani S, Qu Y, Gao B, Boden A, Chintalgattu V, Turk JR, Chan J, Hu LA, Dransfield P, Houze J, Wong J, Ma J, Pattaropong V, Véniant MM, Vargas HM, Swaminath G, Khakoo AY. Ason B, et al. Among authors: chan j. JCI Insight. 2020 Apr 23;5(8):e132898. doi: 10.1172/jci.insight.132898. JCI Insight. 2020. PMID: 32208384 Free PMC article.
Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.
Reed AB, Lanman BA, Holder JR, Yang BH, Ma J, Humphreys SC, Wang Z, Chan JCY, Miranda LP, Swaminath G, Allen JG. Reed AB, et al. Among authors: chan jcy. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127499. doi: 10.1016/j.bmcl.2020.127499. Epub 2020 Aug 26. Bioorg Med Chem Lett. 2020. PMID: 32858124
Impact of AI on the Cyber Kill Chain: A Systematic Review.
Kazimierczak M, Habib N, Chan JH, Thanapattheerakul T. Kazimierczak M, et al. Among authors: chan jh. Heliyon. 2024 Dec 2;10(24):e40699. doi: 10.1016/j.heliyon.2024.e40699. eCollection 2024 Dec 30. Heliyon. 2024. PMID: 39720055 Free PMC article.
9,975 results