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Page 1
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M. Phesse TJ, et al. Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411. Sci Signal. 2014. PMID: 25270258 Free article.
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. Schmidt S, et al. Among authors: afshar sterle s. J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22. J Exp Med. 2018. PMID: 29472497 Free PMC article.
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL. Thilakasiri P, et al. Among authors: afshar sterle s. EMBO Mol Med. 2019 Apr;11(4):e9539. doi: 10.15252/emmm.201809539. EMBO Mol Med. 2019. PMID: 30885958 Free PMC article.
Host IL11 Signaling Suppresses CD4+ T cell-Mediated Antitumor Responses to Colon Cancer in Mice.
Huynh J, Baloyan D, Chisanga D, Shi W, O'Brien M, Afshar-Sterle S, Alorro M, Pang L, Williams DS, Parslow AC, Thilakasiri P, Eissmann MF, Boon L, Masson F, Chand AL, Ernst M. Huynh J, et al. Among authors: afshar sterle s. Cancer Immunol Res. 2021 Jul;9(7):735-747. doi: 10.1158/2326-6066.CIR-19-1023. Epub 2021 Apr 27. Cancer Immunol Res. 2021. PMID: 33906864
Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Luk IY, et al. Among authors: afshar sterle s. Cell Death Differ. 2022 Nov;29(11):2288-2302. doi: 10.1038/s41418-022-01016-w. Epub 2022 May 23. Cell Death Differ. 2022. PMID: 35606410 Free PMC article.
Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death.
Jenkins LJ, Luk IY, Fairlie WD, Lee EF, Palmieri M, Schoffer KL, Tan T, Ng I, Vukelic N, Tran S, Tse JWT, Nightingale R, Alam Z, Chionh F, Iatropoulos G, Ernst M, Afshar-Sterle S, Desai J, Gibbs P, Sieber OM, Dhillon AS, Tebbutt NC, Mariadason JM. Jenkins LJ, et al. Among authors: afshar sterle s. Mol Cancer Ther. 2023 Jan 3;22(1):52-62. doi: 10.1158/1535-7163.MCT-22-0101. Mol Cancer Ther. 2023. PMID: 36343387 Free PMC article.
TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
Yakou MH, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A, Schmid K, Dijkstra C, Inguanti C, Ostrouska S, Wilcox J, Smith M, Parathan P, Allam A, Xue HH, Belz GT, Mariadason JM, Behren A, Drummond GR, Ruscher R, Williams DS, Pal B, Shi W, Ernst M, Raghu D, Mielke LA. Yakou MH, et al. Among authors: afshar sterle s. Sci Immunol. 2023 Oct 13;8(88):eadf2163. doi: 10.1126/sciimmunol.adf2163. Epub 2023 Oct 6. Sci Immunol. 2023. PMID: 37801516
14 results