O'Connell MR - Search Results

1

Programmable RNA recognition and cleavage by CRISPR/Cas9.

O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. O'Connell MR, et al. Nature. 2014 Dec 11;516(7530):263-6. doi: 10.1038/nature13769. Epub 2014 Sep 28. Nature. 2014. PMID: 25274302 Free PMC article.

2

Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.

Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Ma E, et al. Mol Cell. 2015 Nov 5;60(3):398-407. doi: 10.1016/j.molcel.2015.10.030. Mol Cell. 2015. PMID: 26545076 Free PMC article.

3

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. Nelles DA, et al. Cell. 2016 Apr 7;165(2):488-96. doi: 10.1016/j.cell.2016.02.054. Epub 2016 Mar 17. Cell. 2016. PMID: 26997482 Free PMC article.

4

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. East-Seletsky A, et al. Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26. Nature. 2016. PMID: 27669025 Free PMC article.

5

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. East-Seletsky A, et al. Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008. Mol Cell. 2017. PMID: 28475872 Free PMC article.

6

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Knott GJ, et al. Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11. Nat Struct Mol Biol. 2017. PMID: 28892041 Free PMC article.

7

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.

Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. Tambe A, et al. Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105. Cell Rep. 2018. PMID: 30044970 Free PMC article.

8

Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR-Cas Systems.

O'Connell MR. O'Connell MR. J Mol Biol. 2019 Jan 4;431(1):66-87. doi: 10.1016/j.jmb.2018.06.029. Epub 2018 Jun 22. J Mol Biol. 2019. PMID: 29940185 Review.

9

Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time.

Davis BJ, O'Connell MR. Davis BJ, et al. Mol Cell. 2020 Jan 16;77(2):207-209. doi: 10.1016/j.molcel.2019.12.018. Mol Cell. 2020. PMID: 31951545 Free article.

10

Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13.

Burris BJD, Molina Vargas AM, Park BJ, O'Connell MR. Burris BJD, et al. Methods. 2022 Oct;206:58-68. doi: 10.1016/j.ymeth.2022.08.007. Epub 2022 Aug 17. Methods. 2022. PMID: 35987443 Free PMC article.

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