Abe H - Search Results

1

Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin.

Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J. Shimada H, et al. Among authors: abe h. Bioorg Med Chem. 2014 Nov 1;22(21):6174-82. doi: 10.1016/j.bmc.2014.08.024. Epub 2014 Sep 17. Bioorg Med Chem. 2014. PMID: 25282652

2

A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.

Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S. Terauchi M, et al. Among authors: abe h. J Med Chem. 2006 Mar 23;49(6):1900-9. doi: 10.1021/jm051039n. J Med Chem. 2006. PMID: 16539376

3

Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.

Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S. Mochizuki T, et al. Among authors: abe h. J Med Chem. 2006 Sep 21;49(19):5750-8. doi: 10.1021/jm060310d. J Med Chem. 2006. PMID: 16970399

4

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Kobayashi T, Watanabe M, Yoshida A, Yamada S, Ito M, Abe H, Ito Y, Arisawa M, Shuto S. Kobayashi T, et al. Among authors: abe h. Bioorg Med Chem. 2010 Feb;18(3):1076-82. doi: 10.1016/j.bmc.2009.12.046. Epub 2009 Dec 23. Bioorg Med Chem. 2010. PMID: 20045649

5

Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.

Arisawa M, Kasaya Y, Obata T, Sasaki T, Nakamura T, Araki T, Yamamoto K, Sasaki A, Yamano A, Ito M, Abe H, Ito Y, Shuto S. Arisawa M, et al. Among authors: abe h. J Med Chem. 2012 Sep 27;55(18):8152-63. doi: 10.1021/jm301084z. Epub 2012 Sep 6. J Med Chem. 2012. PMID: 22916727

6

Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K. Kumamoto H, et al. Among authors: abe h. J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. J Org Chem. 2016. PMID: 27009432 Free PMC article.

7

Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms.

Fushihara D, Fukuda H, Abe H, Shuto S. Fushihara D, et al. Among authors: abe h. Nucleosides Nucleotides Nucleic Acids. 2019;38(12):921-941. doi: 10.1080/15257770.2019.1625380. Epub 2019 Jun 12. Nucleosides Nucleotides Nucleic Acids. 2019. PMID: 31187692

8

Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside.

Kumamoto H, Kawahigashi S, Wakabayashi H, Nakano T, Miyaike T, Kitagawa Y, Abe H, Ito M, Haraguchi K, Balzarini J, Baba M, Tanaka H. Kumamoto H, et al. Among authors: abe h. Chem Commun (Camb). 2012 Nov 18;48(89):10993-5. doi: 10.1039/c2cc35876j. Chem Commun (Camb). 2012. PMID: 23038212

9

Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.

Haraguchi K, Shimada H, Kimura K, Akutsu G, Tanaka H, Abe H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC, Balzarini J. Haraguchi K, et al. Among authors: abe h. ACS Med Chem Lett. 2011 Sep 8;2(9):692-697. doi: 10.1021/ml2001054. ACS Med Chem Lett. 2011. PMID: 23795238 Free PMC article.

10

Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents.

Yamaguchi K, Kazuta Y, Abe H, Matsuda A, Shuto S. Yamaguchi K, et al. Among authors: abe h. J Org Chem. 2003 Nov 28;68(24):9255-62. doi: 10.1021/jo0302206. J Org Chem. 2003. PMID: 14629144

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