Dirr HW - Search Results

1

Amide hydrogen exchange in HIV-1 subtype B and C proteases--insights into reduced drug susceptibility and dimer stability.

Naicker P, Stoychev S, Dirr HW, Sayed Y. Naicker P, et al. Among authors: dirr hw. FEBS J. 2014 Dec;281(24):5395-410. doi: 10.1111/febs.13084. Epub 2014 Nov 4. FEBS J. 2014. PMID: 25283307 Free article.

2

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.

Naicker P, Achilonu I, Fanucchi S, Fernandes M, Ibrahim MA, Dirr HW, Soliman ME, Sayed Y. Naicker P, et al. Among authors: dirr hw. J Biomol Struct Dyn. 2013 Dec;31(12):1370-80. doi: 10.1080/07391102.2012.736774. Epub 2012 Nov 12. J Biomol Struct Dyn. 2013. PMID: 23140382

3

F99 is critical for dimerization and activation of South African HIV-1 subtype C protease.

Naicker P, Seele P, Dirr HW, Sayed Y. Naicker P, et al. Among authors: dirr hw. Protein J. 2013 Oct;32(7):560-7. doi: 10.1007/s10930-013-9517-y. Protein J. 2013. PMID: 24132393

4

Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.

Zondagh J, Balakrishnan V, Achilonu I, Dirr HW, Sayed Y. Zondagh J, et al. Among authors: dirr hw. J Mol Graph Model. 2018 Jun;82:1-11. doi: 10.1016/j.jmgm.2018.03.006. Epub 2018 Mar 27. J Mol Graph Model. 2018. PMID: 29625416

5

Drug susceptibility and replication capacity of a rare HIV-1 subtype C protease hinge region variant.

Zondagh J, Basson AE, Achilonu I, Morris L, Dirr HW, Sayed Y. Zondagh J, et al. Among authors: dirr hw. Antivir Ther. 2019;24(5):333-342. doi: 10.3851/IMP3308. Antivir Ther. 2019. PMID: 30958309

6

The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability.

Sayed Y, Wallace LA, Dirr HW. Sayed Y, et al. Among authors: dirr hw. FEBS Lett. 2000 Jan 14;465(2-3):169-72. doi: 10.1016/s0014-5793(99)01747-0. FEBS Lett. 2000. PMID: 10631328 Free article.

7

A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.

Dirr HW, Little T, Kuhnert DC, Sayed Y. Dirr HW, et al. J Biol Chem. 2005 May 20;280(20):19480-7. doi: 10.1074/jbc.M413608200. Epub 2005 Mar 9. J Biol Chem. 2005. PMID: 15757902 Free article.

8

The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability.

Alves CS, Kuhnert DC, Sayed Y, Dirr HW. Alves CS, et al. Among authors: dirr hw. Biochem J. 2006 Jan 15;393(Pt 2):523-8. doi: 10.1042/BJ20051066. Biochem J. 2006. PMID: 16190865 Free PMC article.

9

Active-site mutations in the South african human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and thermodynamic study.

Mosebi S, Morris L, Dirr HW, Sayed Y. Mosebi S, et al. Among authors: dirr hw. J Virol. 2008 Nov;82(22):11476-9. doi: 10.1128/JVI.00726-08. Epub 2008 Sep 3. J Virol. 2008. PMID: 18768960 Free PMC article.

10

Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry.

Stoychev SH, Nathaniel C, Fanucchi S, Brock M, Li S, Asmus K, Woods VL Jr, Dirr HW. Stoychev SH, et al. Among authors: dirr hw. Biochemistry. 2009 Sep 8;48(35):8413-21. doi: 10.1021/bi9010607. Biochemistry. 2009. PMID: 19650640 Free PMC article.

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