Young RN - Search Results

1

Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss.

Liu CC, Hu S, Chen G, Georgiou J, Arns S, Kumar NS, Young RN, Grynpas MD. Liu CC, et al. Among authors: young rn. J Bone Miner Res. 2015 Apr;30(4):670-80. doi: 10.1002/jbmr.2382. J Bone Miner Res. 2015. PMID: 25284325 Free article.

2

In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss.

Hu S, Liu CC, Chen G, Willett T, Young RN, Grynpas MD. Hu S, et al. Among authors: young rn. Osteoporos Int. 2016 Feb;27(2):797-808. doi: 10.1007/s00198-015-3284-x. Epub 2015 Aug 14. Osteoporos Int. 2016. PMID: 26272313

3

Targeting therapeutics to bone by conjugation with bisphosphonates.

Young RN, Grynpas MD. Young RN, et al. Curr Opin Pharmacol. 2018 Jun;40:87-94. doi: 10.1016/j.coph.2018.03.010. Epub 2018 Apr 4. Curr Opin Pharmacol. 2018. PMID: 29626715 Review.

4

Determination of the rat in vivo pharmacokinetic profile of a bone-targeting dual-action pro-drug for treatment of osteoporosis.

Chen G, Arns S, Young RN. Chen G, et al. Among authors: young rn. Bioconjug Chem. 2015 Jun 17;26(6):1095-103. doi: 10.1021/acs.bioconjchem.5b00160. Epub 2015 May 15. Bioconjug Chem. 2015. PMID: 25945831

5

In Vivo Bone Effects of a Novel Bisphosphonate-EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model.

Sheikh Z, Chen G, Al-Jaf F, Thévenin M, Banks K, Glogauer M, Young RN, Grynpas MD. Sheikh Z, et al. Among authors: young rn. JBMR Plus. 2019 Nov 9;3(12):e10237. doi: 10.1002/jbm4.10237. eCollection 2019 Dec. JBMR Plus. 2019. PMID: 31844825 Free PMC article.

6

Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects.

Sheikh Z, Abdallah MN, Al-Jaf F, Chen G, Hamdan N, Young RN, Grynpas MD, Glogauer M. Sheikh Z, et al. Among authors: young rn. J Periodontol. 2020 Nov;91(11):1521-1531. doi: 10.1002/JPER.19-0645. Epub 2020 Apr 10. J Periodontol. 2020. PMID: 32100284

7

Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects.

Sheikh Z, Abdallah MN, Al-Jaf F, Chen G, Hamdan N, Young RN, Grynpas MD, Glogauer M. Sheikh Z, et al. Among authors: young rn. J Biomed Mater Res B Appl Biomater. 2020 Aug;108(6):2670-2680. doi: 10.1002/jbm.b.34598. Epub 2020 Mar 11. J Biomed Mater Res B Appl Biomater. 2020. PMID: 32159274

8

Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis.

Xie H, Chen G, Young RN. Xie H, et al. Among authors: young rn. J Med Chem. 2017 Aug 24;60(16):7012-7028. doi: 10.1021/acs.jmedchem.6b00951. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28699744

9

Effects of treatment with a bone-targeted prostaglandin E2 receptor 4 agonist C3 (Mes-1007) in a mouse model of severe osteogenesis imperfecta.

Boraschi-Diaz I, Chen G, Polak-Nachumow J, Young RN, Rauch F. Boraschi-Diaz I, et al. Among authors: young rn. Bone. 2021 Apr;145:115867. doi: 10.1016/j.bone.2021.115867. Epub 2021 Jan 29. Bone. 2021. PMID: 33524637

10

Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis.

Arns S, Gibe R, Moreau A, Monzur Morshed M, Young RN. Arns S, et al. Among authors: young rn. Bioorg Med Chem. 2012 Mar 15;20(6):2131-40. doi: 10.1016/j.bmc.2012.01.024. Epub 2012 Jan 31. Bioorg Med Chem. 2012. PMID: 22341574

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