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5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Takai H, Masuda K, Sato T, Sakaguchi Y, Suzuki T, Suzuki T, Koyama-Nasu R, Nasu-Nishimura Y, Katou Y, Ogawa H, Morishita Y, Kozuka-Hata H, Oyama M, Todo T, Ino Y, Mukasa A, Saito N, Toyoshima C, Shirahige K, Akiyama T. Takai H, et al. Among authors: ino y. Cell Rep. 2014 Oct 9;9(1):48-60. doi: 10.1016/j.celrep.2014.08.071. Epub 2014 Oct 2. Cell Rep. 2014. PMID: 25284789 Free article.
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
Funato K, Hayashi T, Echizen K, Negishi L, Shimizu N, Koyama-Nasu R, Nasu-Nishimura Y, Morishita Y, Tabar V, Todo T, Ino Y, Mukasa A, Saito N, Akiyama T. Funato K, et al. Among authors: ino y. EMBO Rep. 2018 Nov;19(11):e45587. doi: 10.15252/embr.201745587. Epub 2018 Sep 13. EMBO Rep. 2018. PMID: 30213795 Free PMC article.
The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells.
Koyama-Nasu R, Haruta R, Nasu-Nishimura Y, Taniue K, Katou Y, Shirahige K, Todo T, Ino Y, Mukasa A, Saito N, Matsui M, Takahashi R, Hoshino-Okubo A, Sugano H, Manabe E, Funato K, Akiyama T. Koyama-Nasu R, et al. Among authors: ino y. Oncogene. 2014 Apr 24;33(17):2236-44. doi: 10.1038/onc.2013.168. Epub 2013 May 20. Oncogene. 2014. PMID: 23686309
PCDH10 is required for the tumorigenicity of glioblastoma cells.
Echizen K, Nakada M, Hayashi T, Sabit H, Furuta T, Nakai M, Koyama-Nasu R, Nishimura Y, Taniue K, Morishita Y, Hirano S, Terai K, Todo T, Ino Y, Mukasa A, Takayanagi S, Ohtani R, Saito N, Akiyama T. Echizen K, et al. Among authors: ino y. Biochem Biophys Res Commun. 2014 Jan 31;444(1):13-8. doi: 10.1016/j.bbrc.2013.12.138. Epub 2014 Jan 6. Biochem Biophys Res Commun. 2014. PMID: 24406169
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H. Watanabe A, et al. Among authors: ino y. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12384-9. doi: 10.1073/pnas.0906930108. Epub 2011 Jul 12. Proc Natl Acad Sci U S A. 2011. PMID: 21750150 Free PMC article.
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.
Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Miyazono K. Ikushima H, et al. Among authors: ino y. J Biol Chem. 2011 Dec 2;286(48):41434-41441. doi: 10.1074/jbc.M111.300863. Epub 2011 Oct 10. J Biol Chem. 2011. PMID: 21987575 Free PMC article.
We have previously reported that the transforming growth factor-beta (TGF-beta)-Sox4-Sox2 pathway is essential for glioma-initiating cells to retain their stemness, and inhibition of TGF-beta signaling may lead to differentiation of glioma-initiating cells (Ikushima, H., Todo, T. …
We have previously reported that the transforming growth factor-beta (TGF-beta)-Sox4-Sox2 pathway is essential for glioma-initiating cells t …
463 results