Littlechild JA - Search Results

1

Determination of protein-ligand interactions using differential scanning fluorimetry.

Vivoli M, Novak HR, Littlechild JA, Harmer NJ. Vivoli M, et al. Among authors: littlechild ja. J Vis Exp. 2014 Sep 13;(91):51809. doi: 10.3791/51809. J Vis Exp. 2014. PMID: 25285605 Free PMC article.

2

Characterisation of an L-haloacid dehalogenase from the marine psychrophile Psychromonas ingrahamii with potential industrial application.

Novak HR, Sayer C, Panning J, Littlechild JA. Novak HR, et al. Among authors: littlechild ja. Mar Biotechnol (NY). 2013 Dec;15(6):695-705. doi: 10.1007/s10126-013-9522-3. Epub 2013 Aug 16. Mar Biotechnol (NY). 2013. PMID: 23949008

3

Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases.

Cutlan R, De Rose S, Isupov MN, Littlechild JA, Harmer NJ. Cutlan R, et al. Among authors: littlechild ja. Biochim Biophys Acta Proteins Proteom. 2020 Feb;1868(2):140322. doi: 10.1016/j.bbapap.2019.140322. Epub 2019 Nov 16. Biochim Biophys Acta Proteins Proteom. 2020. PMID: 31740415 Review.

4

Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae.

Novak HR, Sayer C, Isupov MN, Gotz D, Spragg AM, Littlechild JA. Novak HR, et al. Among authors: littlechild ja. FEBS Lett. 2014 May 2;588(9):1616-22. doi: 10.1016/j.febslet.2014.02.056. Epub 2014 Mar 5. FEBS Lett. 2014. PMID: 24613925 Free article.

5

Marine Rhodobacteraceae L-haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water.

Novak HR, Sayer C, Isupov MN, Paszkiewicz K, Gotz D, Spragg AM, Littlechild JA. Novak HR, et al. Among authors: littlechild ja. FEBS J. 2013 Apr;280(7):1664-80. doi: 10.1111/febs.12177. Epub 2013 Mar 8. FEBS J. 2013. PMID: 23384397 Free article.

6

Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site.

Sayer C, Finnigan W, Isupov MN, Levisson M, Kengen SW, van der Oost J, Harmer NJ, Littlechild JA. Sayer C, et al. Among authors: littlechild ja. Sci Rep. 2016 May 10;6:25542. doi: 10.1038/srep25542. Sci Rep. 2016. PMID: 27160974 Free PMC article.

7

Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry.

Finnigan W, Thomas A, Cromar H, Gough B, Snajdrova R, Adams JP, Littlechild JA, Harmer NJ. Finnigan W, et al. Among authors: littlechild ja. ChemCatChem. 2017 Mar 20;9(6):1005-1017. doi: 10.1002/cctc.201601249. Epub 2017 Feb 14. ChemCatChem. 2017. PMID: 28450969 Free PMC article.

8

Engineering a Seven Enzyme Biotransformation using Mathematical Modelling and Characterized Enzyme Parts.

Finnigan W, Cutlan R, Snajdrova R, Adams JP, Littlechild JA, Harmer NJ. Finnigan W, et al. Among authors: littlechild ja. ChemCatChem. 2019 Aug 7;11(15):3474-3489. doi: 10.1002/cctc.201900646. Epub 2019 Jul 4. ChemCatChem. 2019. PMID: 31598184 Free PMC article.

9

Site-directed mutagenesis of proline 204 in the 'hinge' region of yeast phosphoglycerate kinase.

McHarg J, Kelly SM, Price NC, Cooper A, Littlechild JA. McHarg J, et al. Among authors: littlechild ja. Eur J Biochem. 1999 Feb;259(3):939-45. doi: 10.1046/j.1432-1327.1999.00133.x. Eur J Biochem. 1999. PMID: 10092885 Free article.

10

Improving the 'tool box' for robust industrial enzymes.

Littlechild JA. Littlechild JA. J Ind Microbiol Biotechnol. 2017 May;44(4-5):711-720. doi: 10.1007/s10295-017-1920-5. Epub 2017 Apr 11. J Ind Microbiol Biotechnol. 2017. PMID: 28401315 Free PMC article. Review.

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