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Page 1
Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.
Büller NV, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JL, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GR, Wildenberg ME, de Sauvage FJ, Muncan V, van den Brink GR. Büller NV, et al. Among authors: medema jp. Gastroenterology. 2015 Jan;148(1):170-180.e6. doi: 10.1053/j.gastro.2014.10.006. Epub 2014 Oct 13. Gastroenterology. 2015. PMID: 25307863
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.
Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF, Raats DA, Sprick MR, Schaefer U, Van Houdt WJ, De Bruijn MT, Schackmann RC, Derksen PW, Medema JP, Walczak H, Borel Rinkes IH, Kranenburg O. Hoogwater FJ, et al. Among authors: medema jp. Gastroenterology. 2010 Jun;138(7):2357-67. doi: 10.1053/j.gastro.2010.02.046. Epub 2010 Feb 23. Gastroenterology. 2010. PMID: 20188103
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP. de Sousa E Melo F, et al. Among authors: medema jp. Cell Stem Cell. 2011 Nov 4;9(5):476-85. doi: 10.1016/j.stem.2011.10.008. Cell Stem Cell. 2011. PMID: 22056143 Free article.
The TNF family member APRIL promotes colorectal tumorigenesis.
Lascano V, Zabalegui LF, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, Versloot M, Rodermond H, van der Loos C, Carvalho-Pinto CE, Kalthoff H, Medema JP, Hahne M. Lascano V, et al. Among authors: medema jp. Cell Death Differ. 2012 Nov;19(11):1826-35. doi: 10.1038/cdd.2012.68. Epub 2012 Jun 15. Cell Death Differ. 2012. PMID: 22705846 Free PMC article.
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
De Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LP, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJ, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L. De Sousa E Melo F, et al. Among authors: medema jp. Nat Med. 2013 May;19(5):614-8. doi: 10.1038/nm.3174. Epub 2013 Apr 14. Nat Med. 2013. PMID: 23584090
Cancer heterogeneity--a multifaceted view.
De Sousa E Melo F, Vermeulen L, Fessler E, Medema JP. De Sousa E Melo F, et al. Among authors: medema jp. EMBO Rep. 2013 Aug;14(8):686-95. doi: 10.1038/embor.2013.92. Epub 2013 Jul 12. EMBO Rep. 2013. PMID: 23846313 Free PMC article. Review.
255 results