Klieber S - Search Results

1

Evaluation of human hepatocytes under prolonged culture in a novel medium for the maintenance of hepatic differentiation: results with the model pro-inflammatory cytokine interleukin 6.

Li AP, Yang Q, Vermet H, Raoust N, Klieber S, Fabre G. Li AP, et al. Among authors: klieber s. Drug Metab Lett. 2014;8(1):12-8. doi: 10.2174/187231280801140929155351. Drug Metab Lett. 2014. PMID: 25313020

2

In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.

Daher W, Pelinski L, Klieber S, Sadoun F, Meunier V, Bourrié M, Biot C, Guillou F, Fabre G, Brocard J, Fraisse L, Maffrand JP, Khalife J, Dive D. Daher W, et al. Among authors: klieber s. Drug Metab Dispos. 2006 Apr;34(4):667-82. doi: 10.1124/dmd.104.003202. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415117

3

Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans.

Klieber S, Hugla S, Ngo R, Arabeyre-Fabre C, Meunier V, Sadoun F, Fedeli O, Rival M, Bourrie M, Guillou F, Maurel P, Fabre G. Klieber S, et al. Drug Metab Dispos. 2008 May;36(5):851-62. doi: 10.1124/dmd.107.019539. Epub 2008 Feb 6. Drug Metab Dispos. 2008. PMID: 18256203

4

The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction.

Klieber S, Torreilles F, Guillou F, Fabre G. Klieber S, et al. Methods Mol Biol. 2010;640:295-308. doi: 10.1007/978-1-60761-688-7_16. Methods Mol Biol. 2010. PMID: 20645059

5

Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds--synthesis and in vitro metabolism of deuterated derivatives of dronedadrone.

Schofield J, Brasseur D, de Bruin B, Vassal T, Klieber S, Arabeyre C, Bourrié M, Sadoun F, Fabre G. Schofield J, et al. Among authors: klieber s. J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):504-12. doi: 10.1002/jlcr.3090. Epub 2013 Sep 4. J Labelled Comp Radiopharm. 2013. PMID: 24285529

6

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.

Vivares A, Salle-Lefort S, Arabeyre-Fabre C, Ngo R, Penarier G, Bremond M, Moliner P, Gallas JF, Fabre G, Klieber S. Vivares A, et al. Among authors: klieber s. Xenobiotica. 2015 Jan;45(1):29-44. doi: 10.3109/00498254.2014.944612. Epub 2014 Jul 28. Xenobiotica. 2015. PMID: 25068923

7

Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug.

Klieber S, Arabeyre-Fabre C, Moliner P, Marti E, Mandray M, Ngo R, Ollier C, Brun P, Fabre G. Klieber S, et al. Pharmacol Res Perspect. 2014 Jun;2(3):e00044. doi: 10.1002/prp2.44. Epub 2014 Apr 22. Pharmacol Res Perspect. 2014. PMID: 25505590 Free PMC article.

8

Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells.

Vermet H, Raoust N, Ngo R, Esserméant L, Klieber S, Fabre G, Boulenc X. Vermet H, et al. Among authors: klieber s. Drug Metab Dispos. 2016 Jan;44(1):50-60. doi: 10.1124/dmd.115.065581. Epub 2015 Oct 14. Drug Metab Dispos. 2016. PMID: 26467767

9

Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.

Da-Silva F, Boulenc X, Vermet H, Compigne P, Gerbal-Chaloin S, Daujat-Chavanieu M, Klieber S, Poulin P. Da-Silva F, et al. Among authors: klieber s. J Pharm Sci. 2018 Jul;107(7):1957-1972. doi: 10.1016/j.xphs.2018.03.001. Epub 2018 Mar 7. J Pharm Sci. 2018. PMID: 29524447

10

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

Vinci B, Duret C, Klieber S, Gerbal-Chaloin S, Sa-Cunha A, Laporte S, Suc B, Maurel P, Ahluwalia A, Daujat-Chavanieu M. Vinci B, et al. Among authors: klieber s. Biotechnol J. 2011 May;6(5):554-64. doi: 10.1002/biot.201000326. Epub 2011 Jan 21. Biotechnol J. 2011. PMID: 21259441 Free PMC article.

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