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Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C. Langhauser F, et al. Among authors: brede m. Blood. 2012 Nov 8;120(19):4082-92. doi: 10.1182/blood-2012-06-440057. Epub 2012 Aug 30. Blood. 2012. PMID: 22936662 Free PMC article.
C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms.
Heydenreich N, Nolte MW, Göb E, Langhauser F, Hofmeister M, Kraft P, Albert-Weissenberger C, Brede M, Varallyay C, Göbel K, Meuth SG, Nieswandt B, Dickneite G, Stoll G, Kleinschnitz C. Heydenreich N, et al. Among authors: brede m. Stroke. 2012 Sep;43(9):2457-67. doi: 10.1161/STROKEAHA.112.660340. Epub 2012 Jun 28. Stroke. 2012. PMID: 22744646
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Göbel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. Kleinschnitz C, et al. Among authors: brede m. Blood. 2013 Jan 24;121(4):679-91. doi: 10.1182/blood-2012-04-426734. Epub 2012 Nov 15. Blood. 2013. PMID: 23160472 Free PMC article.
Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.
Göb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Göbel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C. Göb E, et al. Among authors: brede m. Ann Neurol. 2015 May;77(5):784-803. doi: 10.1002/ana.24380. Epub 2015 Mar 13. Ann Neurol. 2015. PMID: 25628066
76 results