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RhoB determines tumor aggressiveness in a murine EGFRL858R-induced adenocarcinoma model and is a potential prognostic biomarker for Lepidic lung cancer.
Calvayrac O, Pradines A, Raymond-Letron I, Rouquette I, Bousquet E, Lauwers-Cances V, Filleron T, Cadranel J, Beau-Faller M, Casanova A, Milia J, Favre G, Mazières J. Calvayrac O, et al. Clin Cancer Res. 2014 Dec 15;20(24):6541-50. doi: 10.1158/1078-0432.CCR-14-0506. Epub 2014 Oct 15. Clin Cancer Res. 2014. PMID: 25320360
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
Calvayrac O, Mazières J, Figarol S, Marty-Detraves C, Raymond-Letron I, Bousquet E, Farella M, Clermont-Taranchon E, Milia J, Rouquette I, Guibert N, Lusque A, Cadranel J, Mathiot N, Savina A, Pradines A, Favre G. Calvayrac O, et al. EMBO Mol Med. 2017 Feb;9(2):238-250. doi: 10.15252/emmm.201606646. EMBO Mol Med. 2017. PMID: 28003335 Free PMC article.
Molecular biomarkers for lung adenocarcinoma.
Calvayrac O, Pradines A, Pons E, Mazières J, Guibert N. Calvayrac O, et al. Eur Respir J. 2017 Apr 5;49(4):1601734. doi: 10.1183/13993003.01734-2016. Print 2017 Apr. Eur Respir J. 2017. PMID: 28381431 Free article. Review.
RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.
Dubois F, Keller M, Calvayrac O, Soncin F, Hoa L, Hergovich A, Parrini MC, Mazières J, Vaisse-Lesteven M, Camonis J, Levallet G, Zalcman G. Dubois F, et al. Among authors: calvayrac o. Cancer Res. 2016 Mar 15;76(6):1627-40. doi: 10.1158/0008-5472.CAN-15-1008. Epub 2016 Jan 12. Cancer Res. 2016. PMID: 26759237
Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity.
Calvayrac O, Nowosad A, Cabantous S, Lin LP, Figarol S, Jeannot P, Serres MP, Callot C, Perchey RT, Creff J, Taranchon-Clermont E, Rouquette I, Favre G, Pradines A, Manenti S, Mazieres J, Lee H, Besson A. Calvayrac O, et al. J Pathol. 2019 Jan;247(1):60-71. doi: 10.1002/path.5167. Epub 2018 Dec 11. J Pathol. 2019. PMID: 30206932
Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma.
Bousquet Mur E, Bernardo S, Papon L, Mancini M, Fabbrizio E, Goussard M, Ferrer I, Giry A, Quantin X, Pujol JL, Calvayrac O, Moll HP, Glasson Y, Pirot N, Turtoi A, Cañamero M, Wong KK, Yarden Y, Casanova E, Soria JC, Colinge J, Siebel CW, Mazieres J, Favre G, Paz-Ares L, Maraver A. Bousquet Mur E, et al. Among authors: calvayrac o. J Clin Invest. 2020 Feb 3;130(2):612-624. doi: 10.1172/JCI126896. J Clin Invest. 2020. PMID: 31671073 Free PMC article.
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