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The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.
Chan WY, Follows GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic K, Piltz S, Donaldson IJ, Gambardella L, Sablitzky F, Green AR, Kouskoff V, Göttgens B. Chan WY, et al. Among authors: knezevic k. Blood. 2007 Mar 1;109(5):1908-16. doi: 10.1182/blood-2006-05-023226. Epub 2006 Oct 19. Blood. 2007. PMID: 17053063 Free article.
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V, Göttgens B. Pimanda JE, et al. Among authors: knezevic k. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17692-7. doi: 10.1073/pnas.0707045104. Epub 2007 Oct 25. Proc Natl Acad Sci U S A. 2007. PMID: 17962413 Free PMC article.
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, Göttgens B. Landry JR, et al. Among authors: knezevic k. Blood. 2008 Mar 15;111(6):3005-14. doi: 10.1182/blood-2007-07-098830. Epub 2008 Jan 9. Blood. 2008. PMID: 18184866 Free article.
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.
Pimanda JE, Chan WY, Wilson NK, Smith AM, Kinston S, Knezevic K, Janes ME, Landry JR, Kolb-Kokocinski A, Frampton J, Tannahill D, Ottersbach K, Follows GA, Lacaud G, Kouskoff V, Göttgens B. Pimanda JE, et al. Among authors: knezevic k. Blood. 2008 Dec 1;112(12):4512-22. doi: 10.1182/blood-2008-05-157560. Epub 2008 Sep 19. Blood. 2008. PMID: 18805961 Free PMC article.
Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors.
Landry JR, Bonadies N, Kinston S, Knezevic K, Wilson NK, Oram SH, Janes M, Piltz S, Hammett M, Carter J, Hamilton T, Donaldson IJ, Lacaud G, Frampton J, Follows G, Kouskoff V, Göttgens B. Landry JR, et al. Among authors: knezevic k. Blood. 2009 Jun 4;113(23):5783-92. doi: 10.1182/blood-2008-11-187757. Epub 2009 Jan 26. Blood. 2009. PMID: 19171877 Free article.
ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.
Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE. Thoms JA, et al. Among authors: knezevic k. Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2. Blood. 2011. PMID: 21536859 Free article.
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