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Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR. Hilliard JJ, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348518 Free PMC article.
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.
Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR. Hua L, et al. Among authors: hilliard jj. Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295977 Free PMC article.
Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.
Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA. Le VT, et al. Among authors: hilliard jj. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5640-8. doi: 10.1128/AAC.00710-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27401576 Free PMC article.
Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.
Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR. Diep BA, et al. Among authors: hilliard jj. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02456-16. doi: 10.1128/AAC.02456-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28115346 Free PMC article.
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.
Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Cohen TS, et al. Among authors: hilliard jj. Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922. Sci Transl Med. 2016. PMID: 26962155
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK. DiGiandomenico A, et al. Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655. Sci Transl Med. 2014. PMID: 25391481
36 results