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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348524 Free PMC article. Clinical Trial.
A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.
Zalacain M, Biswas S, Ingraham KA, Ambrad J, Bryant A, Chalker AF, Iordanescu S, Fan J, Fan F, Lunsford RD, O'Dwyer K, Palmer LM, So C, Sylvester D, Volker C, Warren P, McDevitt D, Brown JR, Holmes DJ, Burnham MK. Zalacain M, et al. J Mol Microbiol Biotechnol. 2003;6(2):109-26. doi: 10.1159/000076741. J Mol Microbiol Biotechnol. 2003. PMID: 15044829
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.
Min S, Ingraham K, Huang J, McCloskey L, Rilling S, Windau A, Pizzollo J, Butler D, Aubart K, Miller LA, Zalacain M, Holmes DJ, O'Dwyer K. Min S, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4644-52. doi: 10.1128/AAC.00484-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014938 Free PMC article.
Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague.
Jakielaszek C, Hossain M, Qian L, Fishman C, Widdowson K, Hilliard JJ, Mannino F, Raychaudhuri A, Carniel E, Demons S, Heine HS, Hershfield J, Russo R, Mega WM, Revelli D, O'Dwyer K. Jakielaszek C, et al. Sci Transl Med. 2022 Jun;14(647):eabg1787. doi: 10.1126/scitranslmed.abg1787. Epub 2022 Jun 1. Sci Transl Med. 2022. PMID: 35648812
Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge.
Jakielaszek C, Hilliard JJ, Mannino F, Hossain M, Qian L, Fishman C, Chou YL, Henning L, Novak J, Demons S, Hershfield J, O'Dwyer K. Jakielaszek C, et al. Antimicrob Agents Chemother. 2023 May 17;67(5):e0138122. doi: 10.1128/aac.01381-22. Epub 2023 Apr 25. Antimicrob Agents Chemother. 2023. PMID: 37097147 Free PMC article.
Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax.
Hilliard JJ, Jakielaszek C, Mannino F, Hossain M, Qian L, Fishman C, Demons S, Hershfield J, Soffler C, Russo R, Henning L, Novak J, O'Dwyer K. Hilliard JJ, et al. Among authors: o dwyer k. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0149723. doi: 10.1128/aac.01497-23. Epub 2024 Feb 15. Antimicrob Agents Chemother. 2024. PMID: 38358266 Free PMC article.
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