Li Y - Search Results

1

A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.

Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. Zhang X, et al. Among authors: li y. J Biol Chem. 2014 Dec 12;289(50):34851-61. doi: 10.1074/jbc.M114.609636. Epub 2014 Oct 28. J Biol Chem. 2014. PMID: 25352592 Free PMC article.

2

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain.

Shi XP, Chen E, Yin KC, Na S, Garsky VM, Lai MT, Li YM, Platchek M, Register RB, Sardana MK, Tang MJ, Thiebeau J, Wood T, Shafer JA, Gardell SJ. Shi XP, et al. Among authors: li ym. J Biol Chem. 2001 Mar 30;276(13):10366-73. doi: 10.1074/jbc.m009200200. J Biol Chem. 2001. PMID: 11266439 Free article.

3

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ. Shi XP, et al. Among authors: li y. J Biol Chem. 2003 Jun 6;278(23):21286-94. doi: 10.1074/jbc.M209859200. Epub 2003 Mar 27. J Biol Chem. 2003. PMID: 12665519 Free article.

4

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Lai MT, et al. J Biol Chem. 2003 Jun 20;278(25):22475-81. doi: 10.1074/jbc.M300974200. Epub 2003 Apr 8. J Biol Chem. 2003. PMID: 12684521 Free article.

5

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.

Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Wang H, et al. J Biol Chem. 2004 Sep 24;279(39):40560-6. doi: 10.1074/jbc.M404345200. Epub 2004 Jul 7. J Biol Chem. 2004. PMID: 15247291 Free article.

6

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.

Kim SH, Yin YI, Li YM, Sisodia SS. Kim SH, et al. J Biol Chem. 2004 Nov 19;279(47):48615-9. doi: 10.1074/jbc.C400396200. Epub 2004 Sep 29. J Biol Chem. 2004. PMID: 15456788 Free article.

7

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors.

Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Chun J, et al. J Org Chem. 2004 Oct 15;69(21):7344-7. doi: 10.1021/jo0486948. J Org Chem. 2004. PMID: 15471490

8

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.

Tarassishin L, Yin YI, Bassit B, Li YM. Tarassishin L, et al. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. doi: 10.1073/pnas.0408007101. Epub 2004 Nov 24. Proc Natl Acad Sci U S A. 2004. PMID: 15563588 Free PMC article.

9

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.

Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Vetrivel KS, et al. Among authors: li ym. Mol Neurodegener. 2007 Feb 8;2:4. doi: 10.1186/1750-1326-2-4. Mol Neurodegener. 2007. PMID: 17288597 Free PMC article.

10

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. Yin YI, et al. J Biol Chem. 2007 Aug 10;282(32):23639-44. doi: 10.1074/jbc.M704601200. Epub 2007 Jun 7. J Biol Chem. 2007. PMID: 17556361 Free article.

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