Gruber A - Search Results

1

WEDGE: an anticoagulant thrombin mutant produced by autoactivation.

Wood DC, Pelc LA, Pozzi N, Wallisch M, Verbout NG, Tucker EI, Gruber A, Di Cera E. Wood DC, et al. Among authors: gruber a. J Thromb Haemost. 2015 Jan;13(1):111-4. doi: 10.1111/jth.12774. Epub 2014 Nov 29. J Thromb Haemost. 2015. PMID: 25369995 Free PMC article.

2

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo.

Gruber A, Cantwell AM, Di Cera E, Hanson SR. Gruber A, et al. J Biol Chem. 2002 Aug 2;277(31):27581-4. doi: 10.1074/jbc.C200237200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070133 Free article.

3

Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates.

Gruber A, Fernández JA, Bush L, Marzec U, Griffin JH, Hanson SR, DI Cera E. Gruber A, et al. J Thromb Haemost. 2006 Feb;4(2):392-7. doi: 10.1111/j.1538-7836.2006.01760.x. J Thromb Haemost. 2006. PMID: 16420571 Free article.

4

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. Gruber A, et al. Blood. 2007 May 1;109(9):3733-40. doi: 10.1182/blood-2006-07-035147. Epub 2007 Jan 16. Blood. 2007. PMID: 17227834 Free PMC article.

5

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

Berny MA, White TC, Tucker EI, Bush-Pelc LA, Di Cera E, Gruber A, McCarty OJ. Berny MA, et al. Among authors: gruber a. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):329-34. doi: 10.1161/ATVBAHA.107.156273. Epub 2007 Oct 25. Arterioscler Thromb Vasc Biol. 2008. PMID: 17962622

6

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernández JA, Griffin JH, Gruber A, McCarty OJ. White TC, et al. Among authors: gruber a. J Thromb Haemost. 2008 Jun;6(6):995-1002. doi: 10.1111/j.1538-7836.2008.02979.x. J Thromb Haemost. 2008. PMID: 18489431 Free article.

7

Interaction between thrombin mutant W215A/E217A and direct thrombin inhibitor.

Tanaka KA, Gruber A, Szlam F, Bush LA, Hanson SR, Di Cera E. Tanaka KA, et al. Among authors: gruber a. Blood Coagul Fibrinolysis. 2008 Jul;19(5):465-8. doi: 10.1097/MBC.0b013e328304e044. Blood Coagul Fibrinolysis. 2008. PMID: 18600103 Free PMC article. No abstract available.

8

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.

Tucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR. Tucker EI, et al. Among authors: gruber a. Blood. 2009 Jan 22;113(4):936-44. doi: 10.1182/blood-2008-06-163675. Epub 2008 Oct 22. Blood. 2009. PMID: 18945968 Free PMC article.

9

Factor XI contributes to thrombin generation in the absence of factor XII.

Kravtsov DV, Matafonov A, Tucker EI, Sun MF, Walsh PN, Gruber A, Gailani D. Kravtsov DV, et al. Among authors: gruber a. Blood. 2009 Jul 9;114(2):452-8. doi: 10.1182/blood-2009-02-203604. Epub 2009 Apr 7. Blood. 2009. PMID: 19351955 Free PMC article.

10

Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner.

White-Adams TC, Berny MA, Patel IA, Tucker EI, Gailani D, Gruber A, McCarty OJ. White-Adams TC, et al. Among authors: gruber a. J Thromb Haemost. 2010 Jun;8(6):1295-301. doi: 10.1111/j.1538-7836.2010.03850.x. J Thromb Haemost. 2010. PMID: 20796202 Free PMC article.

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