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Page 1
WEDGE: an anticoagulant thrombin mutant produced by autoactivation.
Wood DC, Pelc LA, Pozzi N, Wallisch M, Verbout NG, Tucker EI, Gruber A, Di Cera E. Wood DC, et al. Among authors: pelc la. J Thromb Haemost. 2015 Jan;13(1):111-4. doi: 10.1111/jth.12774. Epub 2014 Nov 29. J Thromb Haemost. 2015. PMID: 25369995 Free PMC article.
Crystal structure of prethrombin-1.
Chen Z, Pelc LA, Di Cera E. Chen Z, et al. Among authors: pelc la. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19278-83. doi: 10.1073/pnas.1010262107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974933 Free PMC article.
Redesigning allosteric activation in an enzyme.
Rana S, Pozzi N, Pelc LA, Di Cera E. Rana S, et al. Among authors: pelc la. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5221-5. doi: 10.1073/pnas.1018860108. Epub 2011 Feb 22. Proc Natl Acad Sci U S A. 2011. PMID: 21368156 Free PMC article.
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. Flick MJ, et al. Among authors: pelc la. Blood. 2011 Jun 9;117(23):6326-37. doi: 10.1182/blood-2010-08-304915. Epub 2011 Mar 24. Blood. 2011. PMID: 21436072 Free PMC article.
Autoactivation of thrombin precursors.
Pozzi N, Chen Z, Zapata F, Niu W, Barranco-Medina S, Pelc LA, Di Cera E. Pozzi N, et al. Among authors: pelc la. J Biol Chem. 2013 Apr 19;288(16):11601-10. doi: 10.1074/jbc.M113.451542. Epub 2013 Mar 6. J Biol Chem. 2013. PMID: 23467412 Free PMC article.
26 results