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The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.
Woehl JL, Stapels DAC, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SHM, Geisbrecht BV. Woehl JL, et al. Among authors: rooijakkers shm. J Immunol. 2014 Dec 15;193(12):6161-6171. doi: 10.4049/jimmunol.1401600. Epub 2014 Nov 7. J Immunol. 2014. PMID: 25381436 Free PMC article.
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Dijkstra DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, Pool J, Kramer CSM, Slot LM, Drijfhout JW, de Vor L, Gelderman KA, Rooijakkers SHM, Zaldumbide A, Vidarsson G, Sharp TH, Parren PWHI, Trouw LA. Dijkstra DJ, et al. Among authors: rooijakkers shm. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310666120. doi: 10.1073/pnas.2310666120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048459 Free PMC article.
Anti-opsonic properties of staphylokinase.
Rooijakkers SH, van Wamel WJ, Ruyken M, van Kessel KP, van Strijp JA. Rooijakkers SH, et al. Microbes Infect. 2005 Mar;7(3):476-84. doi: 10.1016/j.micinf.2004.12.014. Epub 2005 Feb 26. Microbes Infect. 2005. PMID: 15792635 Free article.
Bacterial complement evasion.
Rooijakkers SH, van Strijp JA. Rooijakkers SH, et al. Mol Immunol. 2007 Jan;44(1-3):23-32. doi: 10.1016/j.molimm.2006.06.011. Epub 2006 Jul 27. Mol Immunol. 2007. PMID: 16875737 Review.
108 results