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Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.
Wan WB, Migawa MT, Vasquez G, Murray HM, Nichols JG, Gaus H, Berdeja A, Lee S, Hart CE, Lima WF, Swayze EE, Seth PP. Wan WB, et al. Among authors: berdeja a. Nucleic Acids Res. 2014 Dec 16;42(22):13456-68. doi: 10.1093/nar/gku1115. Epub 2014 Nov 14. Nucleic Acids Res. 2014. PMID: 25398895 Free PMC article.
TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.
Murray S, Ittig D, Koller E, Berdeja A, Chappell A, Prakash TP, Norrbom M, Swayze EE, Leumann CJ, Seth PP. Murray S, et al. Among authors: berdeja a. Nucleic Acids Res. 2012 Jul;40(13):6135-43. doi: 10.1093/nar/gks273. Epub 2012 Mar 30. Nucleic Acids Res. 2012. PMID: 22467214 Free PMC article.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Østergaard ME, De Hoyos CL, Wan WB, Shen W, Low A, Berdeja A, Vasquez G, Murray S, Migawa MT, Liang XH, Swayze EE, Crooke ST, Seth PP. Østergaard ME, et al. Among authors: berdeja a. Nucleic Acids Res. 2020 Feb 28;48(4):1691-1700. doi: 10.1093/nar/gkaa031. Nucleic Acids Res. 2020. PMID: 31980820 Free PMC article.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Anderson BA, Freestone GC, Low A, De-Hoyos CL, Iii WJD, Østergaard ME, Migawa MT, Fazio M, Wan WB, Berdeja A, Scandalis E, Burel SA, Vickers TA, Crooke ST, Swayze EE, Liang X, Seth PP. Anderson BA, et al. Among authors: berdeja a. Nucleic Acids Res. 2021 Sep 20;49(16):9026-9041. doi: 10.1093/nar/gkab718. Nucleic Acids Res. 2021. PMID: 34417625 Free PMC article.
25 results