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Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.
Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M. Xu X, et al. Among authors: oda t. Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10. Biochem Biophys Res Commun. 2010. PMID: 20226167 Free PMC article.
Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.
Kajii T, Kobayashi S, Shiba S, Fujii S, Tamitani M, Kohno M, Nakamura Y, Nanno T, Kato T, Okuda S, Uchinoumi H, Oda T, Yamamoto T, Yano M. Kajii T, et al. Among authors: oda t. Biochem Biophys Res Commun. 2020 Jan 1;521(1):57-63. doi: 10.1016/j.bbrc.2019.10.071. Epub 2019 Oct 18. Biochem Biophys Res Commun. 2020. PMID: 31635807
Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice.
Sufu-Shimizu Y, Okuda S, Kato T, Nishimura S, Uchinoumi H, Oda T, Kobayashi S, Yamamoto T, Yano M. Sufu-Shimizu Y, et al. Among authors: oda t. Biochem Biophys Res Commun. 2020 Apr 2;524(2):431-438. doi: 10.1016/j.bbrc.2020.01.107. Epub 2020 Jan 29. Biochem Biophys Res Commun. 2020. PMID: 32007269
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.
Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Tateishi H, et al. Among authors: oda t. Cardiovasc Res. 2009 Feb 15;81(3):536-45. doi: 10.1093/cvr/cvn303. Epub 2008 Nov 7. Cardiovasc Res. 2009. PMID: 18996969 Free PMC article.
2,642 results