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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Olayanju A, et al. Among authors: park bk. Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14. Free Radic Biol Med. 2015. PMID: 25445704 Free PMC article.
Role of Nrf2 in protection against acute kidney injury.
Shelton LM, Park BK, Copple IM. Shelton LM, et al. Among authors: park bk. Kidney Int. 2013 Dec;84(6):1090-5. doi: 10.1038/ki.2013.248. Epub 2013 Jun 19. Kidney Int. 2013. PMID: 23783243 Free article. Review.
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, Rainbow L, Fang Y, Sutherland JJ, Ellis EC, Ingelman-Sundberg M, Fenwick SW, Goldring CE, van de Water B, Stevens JL, Park BK. Copple IM, et al. Among authors: park bk. Arch Toxicol. 2019 Feb;93(2):385-399. doi: 10.1007/s00204-018-2354-1. Epub 2018 Nov 13. Arch Toxicol. 2019. PMID: 30426165 Free PMC article.
1,551 results