Hayes MP - Search Results

1

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.

Brust TF, Hayes MP, Roman DL, Watts VJ. Brust TF, et al. Among authors: hayes mp. Biochem Pharmacol. 2015 Jan 1;93(1):85-91. doi: 10.1016/j.bcp.2014.10.014. Epub 2014 Nov 7. Biochem Pharmacol. 2015. PMID: 25449598 Free PMC article.

2

Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.

Doyle TB, Hayes MP, Chen DH, Raskind WH, Watts VJ. Doyle TB, et al. Among authors: hayes mp. Biochem Pharmacol. 2019 May;163:169-177. doi: 10.1016/j.bcp.2019.02.005. Epub 2019 Feb 14. Biochem Pharmacol. 2019. PMID: 30772269 Free PMC article.

3

Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ. Brust TF, et al. Among authors: hayes mp. J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24. J Pharmacol Exp Ther. 2015. PMID: 25539635 Free PMC article.

4

Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family.

Hayes MP, Bodle CR, Roman DL. Hayes MP, et al. Mol Pharmacol. 2018 Jan;93(1):25-35. doi: 10.1124/mol.117.109843. Epub 2017 Oct 19. Mol Pharmacol. 2018. PMID: 29051318 Free PMC article.

5

A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling.

Soto-Velasquez M, Hayes MP, Alpsoy A, Dykhuizen EC, Watts VJ. Soto-Velasquez M, et al. Among authors: hayes mp. Mol Pharmacol. 2018 Sep;94(3):963-972. doi: 10.1124/mol.118.111849. Epub 2018 Jun 27. Mol Pharmacol. 2018. PMID: 29950405 Free PMC article.

6

Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase.

Ding Z, Ejendal KFK, Soto-Velasquez M, Hayes MP, Santoro N, Larsen MJ, Watts VJ. Ding Z, et al. Among authors: hayes mp. J Pharmacol Exp Ther. 2020 Mar;372(3):267-276. doi: 10.1124/jpet.119.261255. Epub 2019 Dec 19. J Pharmacol Exp Ther. 2020. PMID: 31857349 Free PMC article.

7

Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers.

Hayes MP, Roman DL. Hayes MP, et al. AAPS J. 2016 May;18(3):550-9. doi: 10.1208/s12248-016-9894-1. Epub 2016 Feb 29. AAPS J. 2016. PMID: 26928451 Free PMC article. Review.

8

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.

Bodle CR, Hayes MP, O'Brien JB, Roman DL. Bodle CR, et al. Among authors: hayes mp. Anal Biochem. 2017 Apr 1;522:10-17. doi: 10.1016/j.ab.2017.01.013. Epub 2017 Jan 20. Anal Biochem. 2017. PMID: 28115169 Free PMC article.

9

Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL. Hayes MP, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):346-357. doi: 10.1021/acschemneuro.7b00349. Epub 2017 Oct 16. ACS Chem Neurosci. 2018. PMID: 28968502 Free PMC article.

10

Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.

Bodle CR, Schamp JH, O'Brien JB, Hayes MP, Wu M, Doorn JA, Roman DL. Bodle CR, et al. Among authors: hayes mp. SLAS Discov. 2018 Apr;23(4):363-374. doi: 10.1177/2472555217752301. Epub 2018 Jan 19. SLAS Discov. 2018. PMID: 29351497 Free PMC article.

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