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214 results

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Page 1
Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.
Tungatt K, Bianchi V, Crowther MD, Powell WE, Schauenburg AJ, Trimby A, Donia M, Miles JJ, Holland CJ, Cole DK, Godkin AJ, Peakman M, Straten PT, Svane IM, Sewell AK, Dolton G. Tungatt K, et al. Among authors: sewell ak. J Immunol. 2015 Jan 1;194(1):463-74. doi: 10.4049/jimmunol.1401785. Epub 2014 Dec 1. J Immunol. 2015. PMID: 25452566 Free PMC article.
High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
Choi EM, Chen JL, Wooldridge L, Salio M, Lissina A, Lissin N, Hermans IF, Silk JD, Mirza F, Palmowski MJ, Dunbar PR, Jakobsen BK, Sewell AK, Cerundolo V. Choi EM, et al. Among authors: sewell ak. J Immunol. 2003 Nov 15;171(10):5116-23. doi: 10.4049/jimmunol.171.10.5116. J Immunol. 2003. PMID: 14607910
Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Wooldridge L, Hutchinson SL, Choi EM, Lissina A, Jones E, Mirza F, Dunbar PR, Price DA, Cerundolo V, Sewell AK. Wooldridge L, et al. Among authors: sewell ak. J Immunol. 2003 Dec 15;171(12):6650-60. doi: 10.4049/jimmunol.171.12.6650. J Immunol. 2003. PMID: 14662868
Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.
Boulter JM, Schmitz N, Sewell AK, Godkin AJ, Bachmann MF, Gallimore AM. Boulter JM, et al. Among authors: sewell ak. Eur J Immunol. 2007 Mar;37(3):798-806. doi: 10.1002/eji.200636743. Eur J Immunol. 2007. PMID: 17295390 Free PMC article.
Human TCR-binding affinity is governed by MHC class restriction.
Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK. Cole DK, et al. Among authors: sewell ak. J Immunol. 2007 May 1;178(9):5727-34. doi: 10.4049/jimmunol.178.9.5727. J Immunol. 2007. PMID: 17442956
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM, Sewell AK, Altfeld M, Brenchley JM, Douek DC, Yang OO, Brander C, Goldstein H, Kan-Mitchell J. Schaubert KL, et al. Among authors: sewell ak. J Immunol. 2007 Jun 15;178(12):7756-66. doi: 10.4049/jimmunol.178.12.7756. J Immunol. 2007. PMID: 17548613 Free PMC article.
214 results