Boyle AJ - Search Results

1

MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using (64)Cu-NOTA-panitumumab F(ab')2 fragments.

Boyle AJ, Cao PJ, Hedley DW, Sidhu SS, Winnik MA, Reilly RM. Boyle AJ, et al. Nucl Med Biol. 2015 Feb;42(2):71-7. doi: 10.1016/j.nucmedbio.2014.10.009. Epub 2014 Oct 22. Nucl Med Biol. 2015. PMID: 25456837

2

Effect of pendant group structure on the hydrolytic stability of polyaspartamide polymers under physiological conditions.

Lu Y, Chau M, Boyle AJ, Liu P, Niehoff A, Weinrich D, Reilly RM, Winnik MA. Lu Y, et al. Among authors: boyle aj. Biomacromolecules. 2012 May 14;13(5):1296-306. doi: 10.1021/bm2018239. Epub 2012 Apr 3. Biomacromolecules. 2012. PMID: 22471754

3

Biotinylated polyacrylamide-based metal-chelating polymers and their influence on antigen recognition following conjugation to a trastuzumab Fab fragment.

Liu P, Boyle AJ, Lu Y, Reilly RM, Winnik MA. Liu P, et al. Among authors: boyle aj. Biomacromolecules. 2012 Sep 10;13(9):2831-42. doi: 10.1021/bm300843u. Epub 2012 Aug 7. Biomacromolecules. 2012. PMID: 22871127

4

The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab Fab fragments on tumor and normal tissue distribution in mice.

Boyle AJ, Liu P, Lu Y, Weinrich D, Scollard DA, Ngo Njock Mbong G, Winnik MA, Reilly RM. Boyle AJ, et al. Pharm Res. 2013 Jan;30(1):104-16. doi: 10.1007/s11095-012-0853-y. Epub 2012 Aug 21. Pharm Res. 2013. PMID: 22907419

5

Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab Fab fragments linked to biotinylated doxorubicin-functionalized metal chelating polymers.

Liu P, Cai Z, Kang JW, Boyle AJ, Adams J, Lu Y, Ngo Ndjock Mbong G, Sidhu S, Reilly RM, Winnik MA. Liu P, et al. Among authors: boyle aj. Biomacromolecules. 2014 Mar 10;15(3):715-25. doi: 10.1021/bm401483a. Epub 2014 Feb 7. Biomacromolecules. 2014. PMID: 24506198

6

Synthesis of polyglutamide-based metal-chelating polymers and their site-specific conjugation to trastuzumab for auger electron radioimmunotherapy.

Lu Y, Ngo Ndjock Mbong G, Liu P, Chan C, Cai Z, Weinrich D, Boyle AJ, Reilly RM, Winnik MA. Lu Y, et al. Among authors: boyle aj. Biomacromolecules. 2014 Jun 9;15(6):2027-37. doi: 10.1021/bm500174p. Epub 2014 May 16. Biomacromolecules. 2014. PMID: 24838009

7

Trastuzumab Labeled to High Specific Activity with (111)In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated Cytotoxicity on HER2-Positive Breast Cancer Cells.

Ngo Ndjock Mbong G, Lu Y, Chan C, Cai Z, Liu P, Boyle AJ, Winnik MA, Reilly RM. Ngo Ndjock Mbong G, et al. Among authors: boyle aj. Mol Pharm. 2015 Jun 1;12(6):1951-60. doi: 10.1021/mp5007618. Epub 2015 May 13. Mol Pharm. 2015. PMID: 25919639

8

Metal-Chelating Polymers (MCPs) with Zwitterionic Pendant Groups Complexed to Trastuzumab Exhibit Decreased Liver Accumulation Compared to Polyanionic MCP Immunoconjugates.

Liu P, Boyle AJ, Lu Y, Adams J, Chi Y, Reilly RM, Winnik MA. Liu P, et al. Among authors: boyle aj. Biomacromolecules. 2015 Nov 9;16(11):3613-23. doi: 10.1021/acs.biomac.5b01066. Epub 2015 Oct 15. Biomacromolecules. 2015. PMID: 26469142

9

Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons.

Aghevlian S, Boyle AJ, Reilly RM. Aghevlian S, et al. Among authors: boyle aj. Adv Drug Deliv Rev. 2017 Jan 15;109:102-118. doi: 10.1016/j.addr.2015.12.003. Epub 2015 Dec 17. Adv Drug Deliv Rev. 2017. PMID: 26705852 Review.

10

Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [⁶⁴Cu]Cu-NOTA-panitumumab F(ab')₂ alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib.

Boyle AJ, Cao PJ, Cai Z, Chan C, Hedley DW, Reilly RM. Boyle AJ, et al. Nucl Med Biol. 2020 May-Jun;84-85:46-54. doi: 10.1016/j.nucmedbio.2020.02.001. Epub 2020 Feb 3. Nucl Med Biol. 2020. PMID: 32062317

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