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Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Wu Y, et al. Among authors: fiorin g. J Am Chem Soc. 2014 Dec 31;136(52):17987-95. doi: 10.1021/ja508461m. Epub 2014 Dec 18. J Am Chem Soc. 2014. PMID: 25470189 Free PMC article.
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML. Acharya R, et al. Among authors: fiorin g. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15075-80. doi: 10.1073/pnas.1007071107. Epub 2010 Aug 5. Proc Natl Acad Sci U S A. 2010. PMID: 20689043 Free PMC article.
Structural biology. The flu's proton escort.
Fiorin G, Carnevale V, DeGrado WF. Fiorin G, et al. Science. 2010 Oct 22;330(6003):456-8. doi: 10.1126/science.1197748. Science. 2010. PMID: 20966238 Free PMC article.
Multiple Proton Confinement in the M2 Channel from the Influenza A Virus.
Carnevale V, Fiorin G, Levine BG, Degrado WF, Klein ML. Carnevale V, et al. Among authors: fiorin g. J Phys Chem C Nanomater Interfaces. 2010 Oct 21;114(48):20856-20863. doi: 10.1021/jp107431g. J Phys Chem C Nanomater Interfaces. 2010. PMID: 21359105 Free PMC article.
57 results