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Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.
Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M. Kozan PA, et al. Among authors: marchelletta rr. J Mol Med (Berl). 2015 May;93(5):535-45. doi: 10.1007/s00109-014-1239-x. Epub 2014 Dec 9. J Mol Med (Berl). 2015. PMID: 25482158 Free PMC article.
Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy.
Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. Das B, et al. Among authors: marchelletta rr. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G580-G591. doi: 10.1152/ajpgi.00098.2019. Epub 2019 Aug 21. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31433211 Free PMC article.
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF. Marchelletta RR, et al. J Clin Invest. 2021 Sep 1;131(17):e138230. doi: 10.1172/JCI138230. J Clin Invest. 2021. PMID: 34623320 Free PMC article.
20 results