Bumbaca D - Search Results

1

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Kamath AV, et al. Among authors: bumbaca d. MAbs. 2014;6(6):1631-7. doi: 10.4161/mabs.36107. MAbs. 2014. PMID: 25484068 Free PMC article.

2

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice.

Bumbaca D, Xiang H, Boswell CA, Port RE, Stainton SL, Mundo EE, Ulufatu S, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Bumbaca D, et al. Br J Pharmacol. 2012 May;166(1):368-77. doi: 10.1111/j.1476-5381.2011.01777.x. Br J Pharmacol. 2012. PMID: 22074316 Free PMC article.

3

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.

Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, Clark S, Ross S, Cheng E, Parsons-Reponte K, Cain G, Van Hoy M, Majidy N, Bheddah S, dela Cruz Chuh J, Kozak KR, Lewin-Koh N, Nauka P, Bumbaca D, Sliwkowski M, Tibbitts J, Theil FP, Fielder PJ, Khawli LA, Boswell CA. Pastuskovas CV, et al. Among authors: bumbaca d. Mol Cancer Ther. 2012 Mar;11(3):752-62. doi: 10.1158/1535-7163.MCT-11-0742-T. Epub 2012 Jan 5. Mol Cancer Ther. 2012. PMID: 22222630

4

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF. Zheng Y, et al. Among authors: bumbaca d. MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453096 Free PMC article.

5

Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.

Boswell CA, Bumbaca D, Fielder PJ, Khawli LA. Boswell CA, et al. Among authors: bumbaca d. AAPS J. 2012 Sep;14(3):612-8. doi: 10.1208/s12248-012-9374-1. Epub 2012 May 31. AAPS J. 2012. PMID: 22648903 Free PMC article.

6

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Yip V, et al. Among authors: bumbaca d. MAbs. 2014 May-Jun;6(3):689-96. doi: 10.4161/mabs.28254. Epub 2014 Feb 26. MAbs. 2014. PMID: 24572100 Free PMC article.

7

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Deng R, et al. Among authors: bumbaca d. MAbs. 2016;8(3):593-603. doi: 10.1080/19420862.2015.1136043. Epub 2016 Feb 26. MAbs. 2016. PMID: 26918260 Free PMC article.

8

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4.

Bumbaca D, Wong A, Drake E, Reyes AE 2nd, Lin BC, Stephan JP, Desnoyers L, Shen BQ, Dennis MS. Bumbaca D, et al. MAbs. 2011 Jul-Aug;3(4):376-86. doi: 10.4161/mabs.3.4.15786. Epub 2011 Jul 1. MAbs. 2011. PMID: 21540647 Free PMC article.

9

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, Theil FP, Fielder PJ, Khawli LA, Lin K. Boswell CA, et al. Among authors: bumbaca d. Bioconjug Chem. 2011 Oct 19;22(10):1994-2004. doi: 10.1021/bc200212a. Epub 2011 Oct 3. Bioconjug Chem. 2011. PMID: 21913715

10

Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow.

Boswell CA, Ferl GZ, Mundo EE, Bumbaca D, Schweiger MG, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. Among authors: bumbaca d. PLoS One. 2011 Mar 15;6(3):e17874. doi: 10.1371/journal.pone.0017874. PLoS One. 2011. PMID: 21436893 Free PMC article.

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