Kamath AV - Search Results

1

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Kamath AV, et al. MAbs. 2014;6(6):1631-7. doi: 10.4161/mabs.36107. MAbs. 2014. PMID: 25484068 Free PMC article.

2

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose.

Kamath AV, Lu D, Gupta P, Jin D, Xiang H, Wong A, Leddy C, Crocker L, Schaefer G, Sliwkowski MX, Damico-Beyer LA. Kamath AV, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):1063-9. doi: 10.1007/s00280-011-1806-6. Epub 2011 Dec 28. Cancer Chemother Pharmacol. 2012. PMID: 22203367

3

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma.

Kamath AV, Lu D, Gupta P, Jin D, Xin Y, Brady A, Stephan JP, Li H, Tien J, Qing J, Damico-Beyer LA. Kamath AV, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):1071-8. doi: 10.1007/s00280-011-1807-5. Epub 2011 Dec 28. Cancer Chemother Pharmacol. 2012. PMID: 22203368

4

Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging.

Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S. Kamath AV, et al. PLoS One. 2012;7(9):e45116. doi: 10.1371/journal.pone.0045116. Epub 2012 Sep 17. PLoS One. 2012. PMID: 23028793 Free PMC article.

5

Challenges and advances in the assessment of the disposition of antibody-drug conjugates.

Kamath AV, Iyer S. Kamath AV, et al. Biopharm Drug Dispos. 2016 Mar;37(2):66-74. doi: 10.1002/bdd.1957. Epub 2015 Jun 8. Biopharm Drug Dispos. 2016. PMID: 25904406 Free PMC article. Review.

6

Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation.

Couch JA, Zhang G, Beyer JC, de Zafra CL, Gupta P, Kamath AV, Lewin-Koh N, Tarrant J, Allamneni KP, Cain G, Yee S, Ross S, Cook R, Tsai SP, Ruppel J, Ridgway JB, Paluch M, Hass PE, Franklin J, Yan M. Couch JA, et al. Among authors: kamath av. Clin Cancer Res. 2016 Mar 15;22(6):1469-79. doi: 10.1158/1078-0432.CCR-15-1380. Epub 2015 Nov 20. Clin Cancer Res. 2016. PMID: 26589434

7

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A.

Gupta P, Kamath AV, Park S, Chiu H, Lutman J, Maia M, Tan MW, Xu M, Swem L, Deng R. Gupta P, et al. Among authors: kamath av. MAbs. 2016 Jul;8(5):991-7. doi: 10.1080/19420862.2016.1167294. Epub 2016 Mar 31. MAbs. 2016. PMID: 27031797 Free PMC article.

8

Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice.

Zhou C, Lehar S, Gutierrez J, Rosenberger CM, Ljumanovic N, Dinoso J, Koppada N, Hong K, Baruch A, Carrasco-Triguero M, Saad O, Mariathasan S, Kamath AV. Zhou C, et al. Among authors: kamath av. MAbs. 2016 Nov/Dec;8(8):1612-1619. doi: 10.1080/19420862.2016.1229722. Epub 2016 Sep 21. MAbs. 2016. PMID: 27653831 Free PMC article.

9

Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.

Stagg NJ, Shen BQ, Brunstein F, Li C, Kamath AV, Zhong F, Schutten M, Fine BM. Stagg NJ, et al. Among authors: kamath av. Regul Toxicol Pharmacol. 2016 Dec;82:1-13. doi: 10.1016/j.yrtph.2016.10.012. Epub 2016 Oct 20. Regul Toxicol Pharmacol. 2016. PMID: 27773754 Review.

10

Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies.

Kamath AV. Kamath AV. Drug Discov Today Technol. 2016 Sep-Dec;21-22:75-83. doi: 10.1016/j.ddtec.2016.09.004. Epub 2016 Oct 24. Drug Discov Today Technol. 2016. PMID: 27978991 Free article. Review.

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