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Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, Graudens E, Mandel J, Laffaire J, Foucquier J, Glibert F, Bertrand V, Nave KA, Sereda MW, Vial E, Guedj M, Hajj R, Nabirotchkin S, Cohen D. Chumakov I, et al. Among authors: nave ka. Orphanet J Rare Dis. 2014 Dec 10;9:201. doi: 10.1186/s13023-014-0201-x. Orphanet J Rare Dis. 2014. PMID: 25491744 Free PMC article.
Mouse models of myelin diseases.
Werner H, Jung M, Klugmann M, Sereda M, Griffiths IR, Nave KA. Werner H, et al. Among authors: nave ka. Brain Pathol. 1998 Oct;8(4):771-93. doi: 10.1111/j.1750-3639.1998.tb00200.x. Brain Pathol. 1998. PMID: 9804383 Free PMC article. Review.
Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov GV, Sereda MW, Brinkmann BG, Fischer TM, Haug B, Birchmeier C, Role L, Lai C, Schwab MH, Nave KA. Michailov GV, et al. Among authors: nave ka. Science. 2004 Apr 30;304(5671):700-3. doi: 10.1126/science.1095862. Epub 2004 Mar 25. Science. 2004. PMID: 15044753
Experimental Charcot-Marie-Tooth type 1A: a cDNA microarrays analysis.
Vigo T, Nobbio L, Hummelen PV, Abbruzzese M, Mancardi G, Verpoorten N, Verhoeven K, Sereda MW, Nave KA, Timmerman V, Schenone A. Vigo T, et al. Among authors: nave ka. Mol Cell Neurosci. 2005 Apr;28(4):703-14. doi: 10.1016/j.mcn.2004.11.016. Mol Cell Neurosci. 2005. PMID: 15797717
377 results