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A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway.
Miyamoto J, Mizukure T, Park SB, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, Tanabe S. Miyamoto J, et al. Among authors: park sb. J Biol Chem. 2015 Jan 30;290(5):2902-18. doi: 10.1074/jbc.M114.610733. Epub 2014 Dec 10. J Biol Chem. 2015. PMID: 25505251 Free PMC article.
Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice.
Kaikiri H, Miyamoto J, Kawakami T, Park SB, Kitamura N, Kishino S, Yonejima Y, Hisa K, Watanabe J, Ogita T, Ogawa J, Tanabe S, Suzuki T. Kaikiri H, et al. Among authors: park sb. Int J Food Sci Nutr. 2017 Dec;68(8):941-951. doi: 10.1080/09637486.2017.1318116. Epub 2017 Apr 24. Int J Food Sci Nutr. 2017. PMID: 28438083
10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.
Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T. Goto T, et al. Among authors: park sb. Biochem Biophys Res Commun. 2015 Apr 17;459(4):597-603. doi: 10.1016/j.bbrc.2015.02.154. Epub 2015 Mar 5. Biochem Biophys Res Commun. 2015. PMID: 25749343
α-Linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40.
Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park SB, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh YS, Jheng HF, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani F, Shimatsu A, Takahashi N, Ogawa J, Satoh-Asahara N, Kawada T. Ohue-Kitano R, et al. Among authors: park sb. FASEB J. 2018 Jan;32(1):304-318. doi: 10.1096/fj.201700273R. Epub 2017 Sep 13. FASEB J. 2018. PMID: 28904023
1,721 results