Boswell CA - Search Results

1

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: boswell ca. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

2

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Yip V, et al. Among authors: boswell ca. MAbs. 2014 May-Jun;6(3):689-96. doi: 10.4161/mabs.28254. Epub 2014 Feb 26. MAbs. 2014. PMID: 24572100 Free PMC article.

3

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.

Bumbaca Yadav D, Sharma VK, Boswell CA, Hotzel I, Tesar D, Shang Y, Ying Y, Fischer SK, Grogan JL, Chiang EY, Urban K, Ulufatu S, Khawli LA, Prabhu S, Joseph S, Kelley RF. Bumbaca Yadav D, et al. Among authors: boswell ca. J Biol Chem. 2015 Dec 11;290(50):29732-41. doi: 10.1074/jbc.M115.692434. Epub 2015 Oct 21. J Biol Chem. 2015. PMID: 26491012 Free PMC article.

4

Effects of charge on antibody tissue distribution and pharmacokinetics.

Boswell CA, Tesar DB, Mukhyala K, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. Bioconjug Chem. 2010 Dec 15;21(12):2153-63. doi: 10.1021/bc100261d. Epub 2010 Nov 5. Bioconjug Chem. 2010. PMID: 21053952 Review.

5

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF. Zheng Y, et al. Among authors: boswell ca. MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453096 Free PMC article.

6

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Kamath AV, et al. Among authors: boswell ca. MAbs. 2014;6(6):1631-7. doi: 10.4161/mabs.36107. MAbs. 2014. PMID: 25484068 Free PMC article.

7

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Deng R, et al. Among authors: boswell ca. MAbs. 2016;8(3):593-603. doi: 10.1080/19420862.2015.1136043. Epub 2016 Feb 26. MAbs. 2016. PMID: 26918260 Free PMC article.

8

Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues.

Boswell CA, Mundo EE, Ulufatu S, Bumbaca D, Cahaya HS, Majidy N, Van Hoy M, Schweiger MG, Fielder PJ, Prabhu S, Khawli LA. Boswell CA, et al. Mol Pharm. 2014 May 5;11(5):1591-8. doi: 10.1021/mp400748t. Epub 2014 Apr 21. Mol Pharm. 2014. PMID: 24702191

9

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.

Shivva V, Boswell CA, Rafidi H, Kelley RF, Kamath AV, Crowell SR. Shivva V, et al. Among authors: boswell ca. Front Pharmacol. 2021 May 6;12:601569. doi: 10.3389/fphar.2021.601569. eCollection 2021. Front Pharmacol. 2021. PMID: 34025395 Free PMC article.

10

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies.

Rafidi H, Rajan S, Urban K, Shatz-Binder W, Hui K, Ferl GZ, Kamath AV, Boswell CA. Rafidi H, et al. Among authors: boswell ca. MAbs. 2022 Jan-Dec;14(1):2085535. doi: 10.1080/19420862.2022.2085535. MAbs. 2022. PMID: 35867780 Free PMC article.

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