Arumugam P - Search Results

1

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency.

Carmo M, Risma KA, Arumugam P, Tiwari S, Hontz AE, Montiel-Equihua CA, Alonso-Ferrero ME, Blundell MP, Schambach A, Baum C, Malik P, Thrasher AJ, Jordan MB, Gaspar HB. Carmo M, et al. Among authors: arumugam p. Mol Ther. 2015 Apr;23(4):737-45. doi: 10.1038/mt.2014.242. Epub 2014 Dec 19. Mol Ther. 2015. PMID: 25523759 Free PMC article.

2

Gene Therapy for beta-thalassemia.

Malik P, Arumugam PI. Malik P, et al. Among authors: arumugam pi. Hematology Am Soc Hematol Educ Program. 2005:45-50. doi: 10.1182/asheducation-2005.1.45. Hematology Am Soc Hematol Educ Program. 2005. PMID: 16304358

3

Successful correction of the human Cooley's anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator.

Malik P, Arumugam PI, Yee JK, Puthenveetil G. Malik P, et al. Among authors: arumugam pi. Ann N Y Acad Sci. 2005;1054:238-49. doi: 10.1196/annals.1345.030. Ann N Y Acad Sci. 2005. PMID: 16339671 Review.

4

Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element.

Arumugam PI, Scholes J, Perelman N, Xia P, Yee JK, Malik P. Arumugam PI, et al. Mol Ther. 2007 Oct;15(10):1863-71. doi: 10.1038/sj.mt.6300259. Epub 2007 Jul 10. Mol Ther. 2007. PMID: 17622240 Free article.

5

Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.

Urbinati F, Arumugam P, Higashimoto T, Perumbeti A, Mitts K, Xia P, Malik P. Urbinati F, et al. Among authors: arumugam p. Mol Ther. 2009 Sep;17(9):1527-36. doi: 10.1038/mt.2009.89. Epub 2009 Apr 21. Mol Ther. 2009. PMID: 19384292 Free PMC article.

6

Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.

Arumugam PI, Higashimoto T, Urbinati F, Modlich U, Nestheide S, Xia P, Fox C, Corsinotti A, Baum C, Malik P. Arumugam PI, et al. Mol Ther. 2009 Nov;17(11):1929-37. doi: 10.1038/mt.2009.183. Epub 2009 Aug 25. Mol Ther. 2009. PMID: 19707188 Free PMC article.

7

The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.

Arumugam PI, Urbinati F, Velu CS, Higashimoto T, Grimes HL, Malik P. Arumugam PI, et al. PLoS One. 2009 Sep 10;4(9):e6995. doi: 10.1371/journal.pone.0006995. PLoS One. 2009. PMID: 19746166 Free PMC article.

8

Genetic therapy for beta-thalassemia: from the bench to the bedside.

Arumugam P, Malik P. Arumugam P, et al. Hematology Am Soc Hematol Educ Program. 2010;2010:445-50. doi: 10.1182/asheducation-2010.1.445. Hematology Am Soc Hematol Educ Program. 2010. PMID: 21239833

9

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.

Zhou X, Florian MC, Arumugam P, Chen X, Cancelas JA, Lang R, Malik P, Geiger H, Zheng Y. Zhou X, et al. Among authors: arumugam p. J Exp Med. 2013 Oct 21;210(11):2371-85. doi: 10.1084/jem.20122348. Epub 2013 Oct 7. J Exp Med. 2013. PMID: 24101377 Free PMC article.

10

Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.

Kiem HP, Arumugam PI, Burtner CR, Fox CF, Beard BC, Dexheimer P, Adair JE, Malik P. Kiem HP, et al. Among authors: arumugam pi. Mol Ther Methods Clin Dev. 2014 Dec 17;1:14055. doi: 10.1038/mtm.2014.55. eCollection 2014. Mol Ther Methods Clin Dev. 2014. PMID: 26052523 Free PMC article.

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