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Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Alvarez-Calderon F, et al. Among authors: kumar v, kumar a. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29. Clin Cancer Res. 2015. PMID: 25547679 Free PMC article.
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. Gregory MA, et al. Among authors: kumar v, kumar a. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. doi: 10.1073/pnas.1603876113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791036 Free PMC article.
Synthesis of novel Ral inhibitors: An in vitro and in vivo study.
Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF. Yan C, et al. Among authors: kumar v, kumar a. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27825764 Free PMC article.
Carnosine protects cardiac myocytes against lipid peroxidation products.
Zhao J, Posa DK, Kumar V, Hoetker D, Kumar A, Ganesan S, Riggs DW, Bhatnagar A, Wempe MF, Baba SP. Zhao J, et al. Among authors: kumar v, kumar a. Amino Acids. 2019 Jan;51(1):123-138. doi: 10.1007/s00726-018-2676-6. Epub 2018 Nov 17. Amino Acids. 2019. PMID: 30449006 Free PMC article.
Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization.
Boakye AA, Zhang D, Guo L, Zheng Y, Hoetker D, Zhao J, Posa DK, Ng CK, Zheng H, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Conklin DJ, Baba SP. Boakye AA, et al. Among authors: kumar v, kumar a. Front Physiol. 2019 Jul 2;10:751. doi: 10.3389/fphys.2019.00751. eCollection 2019. Front Physiol. 2019. PMID: 31312142 Free PMC article.
Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury.
Zhao J, Conklin DJ, Guo Y, Zhang X, Obal D, Guo L, Jagatheesan G, Katragadda K, He L, Yin X, Prodhan MAI, Shah J, Hoetker D, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Baba SP. Zhao J, et al. Among authors: kumar v, kumar a. J Am Heart Assoc. 2020 Jun 16;9(12):e015222. doi: 10.1161/JAHA.119.015222. Epub 2020 Jun 9. J Am Heart Assoc. 2020. PMID: 32515247 Free PMC article.
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