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Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.
Engström P, Nguyen BD, Normark J, Nilsson I, Bastidas RJ, Gylfe A, Elofsson M, Fields KA, Valdivia RH, Wolf-Watz H, Bergström S. Engström P, et al. Among authors: bergstrom s. J Bacteriol. 2013 Sep;195(18):4221-30. doi: 10.1128/JB.00506-13. Epub 2013 Jul 12. J Bacteriol. 2013. PMID: 23852872 Free PMC article.
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F. Good JA, et al. Among authors: bergstrom s. J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22. J Med Chem. 2016. PMID: 26849778
A 2-pyridone amide inhibitor of transcriptional activity in Chlamydia trachomatis.
Núñez-Otero C, Bahnan W, Vielfort K, Silver J, Singh P, Elbir H, Almqvist F, Bergström S, Gylfe Å. Núñez-Otero C, et al. Among authors: bergstrom s. Antimicrob Agents Chemother. 2023 May 1;95(5):e01826-20. doi: 10.1128/AAC.01826-20. Epub 2021 Feb 16. Antimicrob Agents Chemother. 2023. PMID: 33593835 Free PMC article.
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F. Kulén M, et al. Among authors: bergstrom s. Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32206238 Free PMC article.
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis.
Muschiol S, Bailey L, Gylfe A, Sundin C, Hultenby K, Bergström S, Elofsson M, Wolf-Watz H, Normark S, Henriques-Normark B. Muschiol S, et al. Among authors: bergstrom s. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14566-71. doi: 10.1073/pnas.0606412103. Epub 2006 Sep 14. Proc Natl Acad Sci U S A. 2006. PMID: 16973741 Free PMC article.
716 results