Butler KV - Search Results

1

Structure-activity relationship studies of SETD8 inhibitors.

Ma A, Yu W, Xiong Y, Butler KV, Brown PJ, Jin J. Ma A, et al. Among authors: butler kv. Medchemcomm. 2014 Dec;5(12):1892-1898. doi: 10.1039/C4MD00317A. Medchemcomm. 2014. PMID: 25554733 Free PMC article.

2

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J. Ma A, et al. Among authors: butler kv. J Med Chem. 2014 Aug 14;57(15):6822-33. doi: 10.1021/jm500871s. Epub 2014 Jul 25. J Med Chem. 2014. PMID: 25032507 Free PMC article.

3

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Eram MS, et al. Among authors: butler kv. ACS Chem Biol. 2016 Mar 18;11(3):772-781. doi: 10.1021/acschembio.5b00839. Epub 2015 Dec 8. ACS Chem Biol. 2016. PMID: 26598975 Free PMC article.

4

Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.

Butler KV, Bohn K, Hrycyna CA, Jin J. Butler KV, et al. Medchemcomm. 2016 May 1;7(5):1016-1021. doi: 10.1039/C6MD00130K. Epub 2016 Apr 14. Medchemcomm. 2016. PMID: 27547295 Free PMC article.

5

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889. doi: 10.1021/acs.jmedchem.6b01244. Epub 2016 Nov 2. J Med Chem. 2016. PMID: 27804297 Free PMC article.

6

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists.

Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J. Chen X, et al. Among authors: butler kv. J Med Chem. 2016 Dec 8;59(23):10601-10618. doi: 10.1021/acs.jmedchem.6b01208. Epub 2016 Nov 16. J Med Chem. 2016. PMID: 27805392 Free PMC article.

7

Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.

Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK. Jain R, et al. Among authors: butler kv. Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. Sci Rep. 2017. PMID: 28487506 Free PMC article.

8

Report and Application of a Tool Compound Data Set.

Butler KV, MacDonald IA, Hathaway NA, Jin J. Butler KV, et al. J Chem Inf Model. 2017 Nov 27;57(11):2699-2706. doi: 10.1021/acs.jcim.7b00343. Epub 2017 Nov 2. J Chem Inf Model. 2017. PMID: 29035535 Free PMC article.

9

Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.

Butler KV, Chiarella AM, Jin J, Hathaway NA. Butler KV, et al. ACS Synth Biol. 2018 Jan 19;7(1):38-45. doi: 10.1021/acssynbio.7b00295. Epub 2017 Nov 7. ACS Synth Biol. 2018. PMID: 29073761 Free PMC article.

10

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL. McCorvy JD, et al. Among authors: butler kv. Nat Chem Biol. 2018 Feb;14(2):126-134. doi: 10.1038/nchembio.2527. Epub 2017 Dec 11. Nat Chem Biol. 2018. PMID: 29227473 Free PMC article.

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