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A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.
Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM. Tian W, et al. Among authors: valverde ma. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14034-9. doi: 10.1073/pnas.0904084106. Epub 2009 Aug 4. Proc Natl Acad Sci U S A. 2009. PMID: 19666518 Free PMC article.
The progesterone receptor regulates the expression of TRPV4 channel.
Jung C, Fandos C, Lorenzo IM, Plata C, Fernandes J, Gené GG, Vázquez E, Valverde MA. Jung C, et al. Among authors: valverde ma. Pflugers Arch. 2009 Nov;459(1):105-13. doi: 10.1007/s00424-009-0706-7. Epub 2009 Aug 23. Pflugers Arch. 2009. PMID: 19701771
134 results