Oldfield E - Search Results

1

Antibacterial drug leads: DNA and enzyme multitargeting.

Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E. Zhu W, et al. Among authors: oldfield e. J Med Chem. 2015 Feb 12;58(3):1215-27. doi: 10.1021/jm501449u. Epub 2015 Jan 22. J Med Chem. 2015. PMID: 25574764 Free PMC article.

2

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Martin MB, Grimley JS, Lewis JC, Heath HT 3rd, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E. Martin MB, et al. Among authors: oldfield e. J Med Chem. 2001 Mar 15;44(6):909-16. doi: 10.1021/jm0002578. J Med Chem. 2001. PMID: 11300872

3

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.

Montalvetti A, Bailey BN, Martin MB, Severin GW, Oldfield E, Docampo R. Montalvetti A, et al. Among authors: oldfield e. J Biol Chem. 2001 Sep 7;276(36):33930-7. doi: 10.1074/jbc.M103950200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435429 Free article.

4

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.

Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Szabo CM, et al. Among authors: oldfield e. J Med Chem. 2002 May 23;45(11):2185-96. doi: 10.1021/jm010412y. J Med Chem. 2002. PMID: 12014956

5

An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs.

Szabo CM, Martin MB, Oldfield E. Szabo CM, et al. Among authors: oldfield e. J Med Chem. 2002 Jul 4;45(14):2894-903. doi: 10.1021/jm010279+. J Med Chem. 2002. PMID: 12086477

6

Activity of bisphosphonates against Trypanosoma brucei rhodesiense.

Martin MB, Sanders JM, Kendrick H, de Luca-Fradley K, Lewis JC, Grimley JS, Van Brussel EM, Olsen JR, Meints GA, Burzynska A, Kafarski P, Croft SL, Oldfield E. Martin MB, et al. Among authors: oldfield e. J Med Chem. 2002 Jul 4;45(14):2904-14. doi: 10.1021/jm0102809. J Med Chem. 2002. PMID: 12086478

7

Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens.

Gossman W, Oldfield E. Gossman W, et al. Among authors: oldfield e. J Med Chem. 2002 Oct 24;45(22):4868-74. doi: 10.1021/jm020224n. J Med Chem. 2002. PMID: 12383012

8

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.

Montalvetti A, Fernandez A, Sanders JM, Ghosh S, Van Brussel E, Oldfield E, Docampo R. Montalvetti A, et al. Among authors: oldfield e. J Biol Chem. 2003 May 9;278(19):17075-83. doi: 10.1074/jbc.M210467200. Epub 2003 Mar 4. J Biol Chem. 2003. PMID: 12618430 Free article.

9

A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.

Kotsikorou E, Oldfield E. Kotsikorou E, et al. Among authors: oldfield e. J Med Chem. 2003 Jul 3;46(14):2932-44. doi: 10.1021/jm030054u. J Med Chem. 2003. PMID: 12825934

10

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

Sanders JM, Gómez AO, Mao J, Meints GA, Van Brussel EM, Burzynska A, Kafarski P, González-Pacanowska D, Oldfield E. Sanders JM, et al. Among authors: oldfield e. J Med Chem. 2003 Nov 20;46(24):5171-83. doi: 10.1021/jm0302344. J Med Chem. 2003. PMID: 14613320

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