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Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination.
Lofano G, Mancini F, Salvatore G, Cantisani R, Monaci E, Carrisi C, Tavarini S, Sammicheli C, Rossi Paccani S, Soldaini E, Laera D, Finco O, Nuti S, Rappuoli R, De Gregorio E, Bagnoli F, Bertholet S. Lofano G, et al. Among authors: de gregorio e. J Immunol. 2015 Aug 15;195(4):1617-27. doi: 10.4049/jimmunol.1402604. Epub 2015 Jul 13. J Immunol. 2015. PMID: 26170383
Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells.
Cioncada R, Maddaluno M, Vo HTM, Woodruff M, Tavarini S, Sammicheli C, Tortoli M, Pezzicoli A, De Gregorio E, Carroll MC, D'Oro U, Piccioli D. Cioncada R, et al. Among authors: de gregorio e. PLoS One. 2017 Oct 31;12(10):e0185843. doi: 10.1371/journal.pone.0185843. eCollection 2017. PLoS One. 2017. PMID: 29088224 Free PMC article.
Immunology of TLR-independent vaccine adjuvants.
De Gregorio E, D'Oro U, Wack A. De Gregorio E, et al. Curr Opin Immunol. 2009 Jun;21(3):339-45. doi: 10.1016/j.coi.2009.05.003. Epub 2009 Jun 1. Curr Opin Immunol. 2009. PMID: 19493664 Review.
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.
Seubert A, Calabro S, Santini L, Galli B, Genovese A, Valentini S, Aprea S, Colaprico A, D'Oro U, Giuliani MM, Pallaoro M, Pizza M, O'Hagan DT, Wack A, Rappuoli R, De Gregorio E. Seubert A, et al. Among authors: de gregorio e. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11169-74. doi: 10.1073/pnas.1107941108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690334 Free PMC article.
MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.
Mastelic Gavillet B, Eberhardt CS, Auderset F, Castellino F, Seubert A, Tregoning JS, Lambert PH, de Gregorio E, Del Giudice G, Siegrist CA. Mastelic Gavillet B, et al. Among authors: de gregorio e. J Immunol. 2015 May 15;194(10):4836-45. doi: 10.4049/jimmunol.1402071. Epub 2015 Apr 13. J Immunol. 2015. PMID: 25870238
Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.
Knudsen NP, Olsen A, Buonsanti C, Follmann F, Zhang Y, Coler RN, Fox CB, Meinke A, D'Oro U, Casini D, Bonci A, Billeskov R, De Gregorio E, Rappuoli R, Harandi AM, Andersen P, Agger EM. Knudsen NP, et al. Among authors: de gregorio e. Sci Rep. 2016 Jan 21;6:19570. doi: 10.1038/srep19570. Sci Rep. 2016. PMID: 26791076 Free PMC article.
176 results