Varmus H - Search Results

1

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.

Song X, Fan PD, Bantikassegn A, Guha U, Threadgill DW, Varmus H, Politi K. Song X, et al. Among authors: varmus h. Cancer Res. 2015 Mar 15;75(6):1035-45. doi: 10.1158/0008-5472.CAN-13-1625. Epub 2015 Jan 16. Cancer Res. 2015. PMID: 25596284 Free PMC article.

2

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.

Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE. Orsulic S, et al. Cancer Cell. 2002 Feb;1(1):53-62. doi: 10.1016/s1535-6108(01)00002-2. Cancer Cell. 2002. PMID: 12086888 Free PMC article.

3

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. Pao W, et al. Among authors: varmus h. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi: 10.1073/pnas.0405220101. Epub 2004 Aug 25. Proc Natl Acad Sci U S A. 2004. PMID: 15329413 Free PMC article.

4

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.

Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, Zakowski MF, Heelan RT, Kris MG, Varmus HE. Pao W, et al. PLoS Med. 2005 Jan;2(1):e17. doi: 10.1371/journal.pmed.0020017. Epub 2005 Jan 25. PLoS Med. 2005. PMID: 15696205 Free PMC article.

5

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Pao W, et al. Among authors: varmus h. PLoS Med. 2005 Mar;2(3):e73. doi: 10.1371/journal.pmed.0020073. Epub 2005 Feb 22. PLoS Med. 2005. PMID: 15737014 Free PMC article.

6

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.

Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Politi K, et al. Genes Dev. 2006 Jun 1;20(11):1496-510. doi: 10.1101/gad.1417406. Epub 2006 May 16. Genes Dev. 2006. PMID: 16705038 Free PMC article.

7

Oncogenes come of age.

Varmus H, Pao W, Politi K, Podsypanina K, Du YC. Varmus H, et al. Cold Spring Harb Symp Quant Biol. 2005;70:1-9. doi: 10.1101/sqb.2005.70.039. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869733 Free PMC article. Review.

8

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, Mardis ER, Wilson RK, Kris MG, Rusch VW, Varmus H, Pao W. Marks JL, et al. Among authors: varmus h. PLoS One. 2007 May 9;2(5):e426. doi: 10.1371/journal.pone.0000426. PLoS One. 2007. PMID: 17487277 Free PMC article.

9

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.

Podsypanina K, Politi K, Beverly LJ, Varmus HE. Podsypanina K, et al. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5242-7. doi: 10.1073/pnas.0801197105. Epub 2008 Mar 20. Proc Natl Acad Sci U S A. 2008. PMID: 18356293 Free PMC article.

10

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.

Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE. Guha U, et al. Among authors: varmus he. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14112-7. doi: 10.1073/pnas.0806158105. Epub 2008 Sep 5. Proc Natl Acad Sci U S A. 2008. PMID: 18776048 Free PMC article.

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