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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.
Ben-Chetrit N, Chetrit D, Russell R, Körner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, Barr H, Seger D, Ferraro DA, Pareja F, Gil-Henn H, Lapidot T, Alon R, Milanezi F, Symons M, Ben-Hamo R, Efroni S, Schmitt F, Wiemann S, Caldas C, Ehrlich M, Yarden Y. Ben-Chetrit N, et al. Among authors: koestler wj. Sci Signal. 2015 Jan 20;8(360):ra7. doi: 10.1126/scisignal.2005537. Sci Signal. 2015. PMID: 25605973
High turnover of extracellular matrix reflected by specific protein fragments measured in serum is associated with poor outcomes in two metastatic breast cancer cohorts.
Lipton A, Leitzel K, Ali SM, Polimera HV, Nagabhairu V, Marks E, Richardson AE, Krecko L, Ali A, Koestler W, Esteva FJ, Leeming DJ, Karsdal MA, Willumsen N. Lipton A, et al. Int J Cancer. 2018 Dec 1;143(11):3027-3034. doi: 10.1002/ijc.31627. Epub 2018 Sep 29. Int J Cancer. 2018. PMID: 29923614 Clinical Trial.
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