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Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.
Spooner J, Keen J, Nayyar K, Birkett N, Bond N, Bannister D, Tigue N, Higazi D, Kemp B, Vaughan T, Kippen A, Buchanan A. Spooner J, et al. Among authors: bond n. Biotechnol Bioeng. 2015 Jul;112(7):1472-7. doi: 10.1002/bit.25550. Epub 2015 Mar 12. Biotechnol Bioeng. 2015. PMID: 25619171
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.
Cohen ES, Scott IC, Majithiya JB, Rapley L, Kemp BP, England E, Rees DG, Overed-Sayer CL, Woods J, Bond NJ, Veyssier CS, Embrey KJ, Sims DA, Snaith MR, Vousden KA, Strain MD, Chan DT, Carmen S, Huntington CE, Flavell L, Xu J, Popovic B, Brightling CE, Vaughan TJ, Butler R, Lowe DC, Higazi DR, Corkill DJ, May RD, Sleeman MA, Mustelin T. Cohen ES, et al. Nat Commun. 2015 Sep 14;6:8327. doi: 10.1038/ncomms9327. Nat Commun. 2015. PMID: 26365875 Free PMC article.
The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan.
Tsui P, Higazi DR, Wu Y, Dunmore R, Solier E, Kasali T, Bond NJ, Huntington C, Carruthers A, Hood J, Borrok MJ, Barnes A, Rickert K, Phipps S, Shirinian L, Zhu J, Bowen MA, Dall'Acqua W, Murray LA. Tsui P, et al. MAbs. 2017 Jan;9(1):104-113. doi: 10.1080/19420862.2016.1255390. Epub 2016 Nov 11. MAbs. 2017. PMID: 27834568 Free PMC article.
Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment.
Chodorge M, Celeste AJ, Grimsby J, Konkar A, Davidsson P, Fairman D, Jenkinson L, Naylor J, White N, Seaman JC, Dickson K, Kemp B, Spooner J, Rossy E, Hornigold DC, Trevaskis JL, Bond NJ, London TB, Buchanan A, Vaughan T, Rondinone CM, Osbourn JK. Chodorge M, et al. Among authors: bond nj. Sci Rep. 2018 Dec 3;8(1):17545. doi: 10.1038/s41598-018-35869-4. Sci Rep. 2018. PMID: 30510163 Free PMC article.
An in vivo platform to select and evolve aggregation-resistant proteins.
Ebo JS, Saunders JC, Devine PWA, Gordon AM, Warwick AS, Schiffrin B, Chin SE, England E, Button JD, Lloyd C, Bond NJ, Ashcroft AE, Radford SE, Lowe DC, Brockwell DJ. Ebo JS, et al. Nat Commun. 2020 Apr 14;11(1):1816. doi: 10.1038/s41467-020-15667-1. Nat Commun. 2020. PMID: 32286330 Free PMC article.
181 results